Daniel E Kaufmann
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Explore the profile of Daniel E Kaufmann including associated specialties, affiliations and a list of published articles.
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Articles
151
Citations
8754
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Recent Articles
1.
Distinct peripheral pro-inflammatory profile associated with tuberous sclerosis complex and epilepsy
Balthazard R, Drouin-Engler R, Bertrand S, Zine-Eddine F, Li J, Tastet O, et al.
Epilepsia
. 2025 Jan;
PMID: 39817839
Objective: Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most...
2.
Mu Z, Randolph H, Aguirre-Gamboa R, Ketter E, Dumaine A, Locher V, et al.
medRxiv
. 2024 Dec;
PMID: 39711700
Only a third of immune-associated loci from genome-wide association studies (GWAS) colocalize with expression quantitative trait loci (eQTLs). To learn about causal genes and mechanisms at the remaining loci, we...
3.
Randolph H, Aguirre-Gamboa R, Brunet-Ratnasingham E, Nakanishi T, Locher V, Ketter E, et al.
bioRxiv
. 2024 Dec;
PMID: 39677792
Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. However, the underlying -regulatory...
4.
Kabakibo T, Arnold E, Padhan K, Lemieux A, Ortega-Delgado G, Routy J, et al.
iScience
. 2024 Oct;
27(10):110947.
PMID: 39381752
T cell immune dysfunction is a prominent feature of chronic HIV infection. To evaluate non-specific dysfunction, a method involving both generic activation and T cell receptor (TCR) stimulation is necessary....
5.
Richard J, Sannier G, Zhu L, Prevost J, Marchitto L, Benlarbi M, et al.
mBio
. 2024 Oct;
15(11):e0182724.
PMID: 39373535
Importance: Antibody-dependent cellular cytotoxicity (ADCC) represents an effective immune response for clearing virally infected cells, making ADCC-mediating antibodies promising therapeutic candidates for HIV-1 cure strategies. Broadly neutralizing antibodies (bNAbs) target...
6.
Lamarche C, Tennankore K, Marchitto L, Beabien-Souligny W, Goupil R, Nadeau-Fredette A, et al.
Kidney Int Rep
. 2024 Aug;
9(8):2575-2577.
PMID: 39156179
No abstract available.
7.
Gazeau S, Deng X, Brunet-Ratnasingham E, Kaufmann D, Larochelle C, Morel P, et al.
bioRxiv
. 2024 Aug;
PMID: 39131351
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in millions of deaths globally. Adults with immunosuppression (e.g., solid organ transplant recipients) and those undergoing active...
8.
Brunet-Ratnasingham E, Morin S, Randolph H, Labrecque M, Belair J, Lima-Barbosa R, et al.
Nat Commun
. 2024 May;
15(1):4177.
PMID: 38755196
Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients...
9.
Fournelle D, Mostefai F, Brunet-Ratnasingham E, Poujol R, Grenier J, Galvez J, et al.
Viruses
. 2024 Mar;
16(3).
PMID: 38543708
Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known...
10.
Rhodes J, Aumon A, Morin S, Girard M, Larochelle C, Brunet-Ratnasingham E, et al.
bioRxiv
. 2024 Jan;
PMID: 38293135
Dimensionality reduction-based data visualization is pivotal in comprehending complex biological data. The most common methods, such as PHATE, t-SNE, and UMAP, are unsupervised and therefore reflect the dominant structure in...