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Daniel Floryk

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Citations 125
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Recent Articles
1.
Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, et al.
Mol Cell Endocrinol . 2011 Jul; 345(1-2):58-67. PMID: 21782885
We analyzed the effects of castration on epididymal white adipose tissue (WAT) in C57BL/6J mice which were fed a regular or high-fat diet. Fourteen days following surgical castration profound effects...
2.
Gao Y, Ishiyama H, Sun M, Brinkman K, Wang X, Zhu J, et al.
Radiat Oncol . 2011 Apr; 6:39. PMID: 21496273
Background: Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated...
3.
Floryk D, Thompson T
Int J Cancer . 2008 Aug; 123(10):2294-302. PMID: 18712736
Inosine 5-monophosphate dehydrogenase II, a key enzyme in the de novo synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive...
4.
Floryk D, Thompson T
Cancer Lett . 2008 Apr; 266(2):216-26. PMID: 18395973
We analyzed the mechanism of action for perifosine (D-21266), a new synthetic alkylphospholipid Akt inhibitor, using LNCaP and PC-3 prostate cancer cells. Perifosine treatment of PC-3 cells resulted in cytostatic...
5.
Floryk D, Huberman E
Cancer Res . 2005 Dec; 65(24):11588-96. PMID: 16357169
Recently, we have reported that inosine 5'-monophosphate dehydrogenase inhibitors, such as mycophenolic acid (MPA), induce the differentiation of PC-3 cells, which are derived from a human androgen-independent prostate cancer, into...
6.
Floryk D, Huberman E
Cancer Lett . 2005 Dec; 231(1):20-9. PMID: 16356827
Inosine 5'-monophosphate dehydrogenase inhibitors including mycophenolic acid (MPA) are effective inducers of terminal differentiation in a variety of distinct human tumor cell types. Here, we report that MPA also induces...
7.
Floryk D, Tollaksen S, Giometti C, Huberman E
Cancer Res . 2004 Dec; 64(24):9049-56. PMID: 15604271
To establish a system to study differentiation therapy drugs, we used the androgen-independent human prostate PC-3 tumor cell line as a target and mycophenolic acid (MPA), tiazofurin, or ribavirin, which...
8.
Drahota Z, Chowdhury S, Floryk D, Mracek T, Wilhelm J, Rauchova H, et al.
J Bioenerg Biomembr . 2002 May; 34(2):105-13. PMID: 12018887
Oxidation of glycerophosphate (GP) by brown adipose tissue mitochondria in the presence of antimycin A was found to be accompanied by significant production of hydrogen peroxide. GP-dependent hydrogen peroxide production...