Daniel D Loeb
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Explore the profile of Daniel D Loeb including associated specialties, affiliations and a list of published articles.
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31
Citations
665
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Recent Articles
1.
Romero S, Unchwaniwala N, Evans 3rd E, Eliceiri K, Loeb D, Sherer N
mBio
. 2023 Feb;
14(2):e0330322.
PMID: 36809075
Hepatitis B virus (HBV) capsid assembly is traditionally thought to occur predominantly in the cytoplasm, where the virus gains access to the virion egress pathway. To better define sites of...
2.
Taha T, Anirudhan V, Limothai U, Loeb D, Petukhov P, McLachlan A
PLoS Pathog
. 2020 Aug;
16(8):e1008802.
PMID: 32822428
Hepatitis B virus (HBV) is a worldwide health problem without curative treatments. Investigation of the regulation of HBV biosynthesis by class I and II histone deacetylases (HDACs) demonstrated that catalytically...
3.
Unchwaniwala N, Sherer N, Loeb D
J Virol
. 2016 Jul;
90(19):8705-19.
PMID: 27440888
Unlabelled: To understand subcellular sites of hepatitis B virus (HBV) replication, we visualized core (Cp), polymerase (Pol), and pregenomic RNA (pgRNA) in infected cells. Interestingly, we found that the majority...
4.
Tan Z, Pionek K, Unchwaniwala N, Maguire M, Loeb D, Zlotnick A
J Virol
. 2015 Jan;
89(6):3275-84.
PMID: 25568211
Unlabelled: Hepatitis B virus (HBV) capsid proteins (Cps) assemble around the pregenomic RNA (pgRNA) and viral reverse transcriptase (P). pgRNA is then reverse transcribed to double-stranded DNA (dsDNA) within the...
5.
Wang J, Nickens D, Lentz T, Loeb D, Zlotnick A
Proc Natl Acad Sci U S A
. 2014 Jul;
111(31):11329-34.
PMID: 25034253
Assembly of a hepatitis B virus (HBV) virion begins with the formation of an RNA-filled core composed of a symmetrical capsid (built of core protein), viral pregenomic RNA, and viral...
6.
Greco N, Hayes M, Loeb D
J Virol
. 2014 Jul;
88(18):10705-13.
PMID: 24991016
Unlabelled: Hepadnaviruses selectively package capsids containing mature double-stranded DNA (dsDNA) genomes in virions. Snow goose hepatitis B virus (SGHBV) is the only known hepadnavirus that packages capsids containing single-stranded DNA...
7.
Tan Z, Maguire M, Loeb D, Zlotnick A
J Virol
. 2013 Jan;
87(6):3208-16.
PMID: 23283960
Capsid (core) assembly is essential for hepatitis B virus (HBV) replication. We hypothesize that assembly kinetics and stability are tuned for optimal viral replication, not maximal assembly. Assembly effectors (AEfs)...
8.
Lentz T, Loeb D
J Virol
. 2011 Sep;
85(22):11916-27.
PMID: 21900164
Covalently closed circular DNA (cccDNA), the nuclear form of hepatitis B virus (HBV), is synthesized by repair of the relaxed circular (RC) DNA genome. Initially, cccDNA is derived from RC...
9.
Lewellyn E, Loeb D
PLoS One
. 2011 Mar;
6(2):e17202.
PMID: 21358805
The core protein of hepatitis B virus can be phosphorylated at serines 155, 162, and 170. The contribution of these serine residues to DNA synthesis was investigated. Core protein mutants...
10.
Lewellyn E, Loeb D
J Virol
. 2010 Nov;
85(3):1298-309.
PMID: 21084467
The carboxy-terminal domain (CTD) of the core protein of hepatitis B virus is not necessary for capsid assembly. However, the CTD does contribute to encapsidation of pregenomic RNA (pgRNA). The...