Daniel D Loeb
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Explore the profile of Daniel D Loeb including associated specialties, affiliations and a list of published articles.
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31
Citations
665
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Recent Articles
11.
Maguire M, Loeb D
J Virol
. 2010 Oct;
84(24):12824-31.
PMID: 20926578
Hepadnaviruses are DNA viruses that are found in several mammalian and avian species. These viruses replicate their genome through reverse transcription of an RNA intermediate termed pregenomic RNA (pgRNA). pgRNA...
12.
Lentz T, Loeb D
J Virol Methods
. 2010 Jul;
169(1):52-60.
PMID: 20600328
Establishment of an infection with hepatitis B virus (HBV) requires synthesis and maintenance of a covalently closed circular DNA (cccDNA) form of the viral genome in the nucleus of host...
13.
Porterfield J, Dhason M, Loeb D, Nassal M, Stray S, Zlotnick A
J Virol
. 2010 Apr;
84(14):7174-84.
PMID: 20427522
A critical feature of a viral life cycle is the ability to selectively package the viral genome. In vivo, phosphorylated hepatitis B virus (HBV) core protein specifically encapsidates a complex...
14.
Abraham T, Lewellyn E, Haines K, Loeb D
Virology
. 2008 Jul;
379(1):30-7.
PMID: 18657840
Hepatitis B virus synthesizes multiple spliced RNAs that can be reverse transcribed into viral DNA. We thoroughly characterized the contribution of spliced RNAs to DNA synthesis in transfected cultures of...
15.
Abraham T, Loeb D
J Virol
. 2007 Aug;
81(21):11577-84.
PMID: 17699570
Previous analysis of hepatitis B virus (HBV) indicated base pairing between two cis-acting sequences, the 5' half of the upper stem of epsilon and phi, contributes to the synthesis of...
16.
Haines K, Loeb D
J Mol Biol
. 2007 May;
370(3):471-80.
PMID: 17531265
For hepadnaviruses, the RNA primer for plus-strand DNA synthesis is generated by the final RNase H cleavage of the pregenomic RNA at an 11 nt sequence called DR1 during the...
17.
Lewellyn E, Loeb D
J Virol
. 2007 Apr;
81(12):6207-15.
PMID: 17409141
Hepadnaviruses utilize two template switches (primer translocation and circularization) during synthesis of plus-strand DNA to generate a relaxed-circular (RC) DNA genome. In duck hepatitis B virus (DHBV) three cis-acting sequences,...
18.
Habig J, Loeb D
J Mol Biol
. 2006 Sep;
364(1):32-43.
PMID: 17005197
There are two mutually exclusive pathways for plus-strand DNA synthesis in hepadnavirus reverse transcription. The predominant pathway gives rise to relaxed circular DNA, while the other pathway yields duplex linear...
19.
Abraham T, Loeb D
J Virol
. 2006 Apr;
80(9):4380-7.
PMID: 16611897
Synthesis of minus-strand DNA of human hepatitis B virus (HBV) can be divided into three phases: initiation of DNA synthesis, the template switch, and elongation of minus-strand DNA. Although much...
20.
Ostrow K, Loeb D
J Virol
. 2004 Jul;
78(16):8780-7.
PMID: 15280486
Packaging of hepadnavirus pregenomic RNA (pgRNA) into capsids, or encapsidation, requires several viral components. The viral polymerase (P) and the capsid subunit (C) are necessary for pgRNA encapsidation. Previous studies...