Daniel D Billadeau
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Explore the profile of Daniel D Billadeau including associated specialties, affiliations and a list of published articles.
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196
Citations
8263
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Recent Articles
1.
Ham H, Isham C, Ristagno E, Correia C, Ennis S, Kandasamy R, et al.
J Allergy Clin Immunol
. 2025 Mar;
PMID: 40072380
Background: The few reported patients with pathogenic IRF8 variants have manifested 2 distinct phenotypes: (1) an autosomal recessive severe immunodeficiency with significant neutrophilia and absence of or significant decrease in...
2.
Steen T, Espinoza I, Duran C, Casadevall G, Serrano-Hervas E, Cuyas E, et al.
Neoplasia
. 2025 Feb;
62:101143.
PMID: 39999714
Resistance to mitochondrial apoptosis is a major driver of chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, pharmacological manipulation of the mitochondrial apoptosis threshold in PDAC cells remains an unmet therapeutic...
3.
Ham H, Hirdler J, Bihnam D, Mao Z, Gicobi J, Macedo B, et al.
Nat Commun
. 2025 Feb;
16(1):1628.
PMID: 39952956
During infection and cancer, mTORC1-mediated metabolic regulation impacts CD8 T cell effector expansion and memory development. However, the mechanisms by which CD8 T cells regulate mTORC1 to support their unique...
4.
Mao Z, Hirdler J, Gicobi J, Maynes M, Hsu M, Dellacecca E, et al.
bioRxiv
. 2025 Jan;
PMID: 39868106
Durable T cell immunity against cancer depends on the continual replenishment of effector CD8+ T cells. Thymic output has been correlated with favorable prognosis in cancer patients across a range...
5.
Singla A, Boesch D, Fung H, Ngoka C, Enriquez A, Song R, et al.
Nat Commun
. 2024 Nov;
15(1):10193.
PMID: 39587083
During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its importance, the mechanisms underlying this interaction...
6.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik J, Chen Y, et al.
Nat Commun
. 2024 Nov;
15(1):10163.
PMID: 39580479
Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient...
7.
Ham H, Jing H, Lamborn I, Kober M, Koval A, Berchiche Y, et al.
Science
. 2024 Sep;
385(6715):eadd8947.
PMID: 39298586
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in , which encodes G, a key component in heterotrimeric G...
8.
Schultz D, Davies B, Payne J, Martin C, Minard A, Childs B, et al.
J Cell Sci
. 2024 Aug;
137(18).
PMID: 39155850
His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) facilitates function of the endosomal sorting complexes required for transport (ESCRTs) during multivesicular body (MVB) formation. To uncover its role...
9.
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, et al.
Cell
. 2024 Jul;
187(16):4272-4288.e20.
PMID: 39013469
Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats...
10.
Shang Z, Zhang S, Wang J, Zhou L, Zhang X, Billadeau D, et al.
Nat Commun
. 2024 May;
15(1):4127.
PMID: 38750080
Stress granules (SGs) are induced by various environmental stressors, resulting in their compositional and functional heterogeneity. SGs play a crucial role in the antiviral process, owing to their potent translational...