Daniel B Constam
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Explore the profile of Daniel B Constam including associated specialties, affiliations and a list of published articles.
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41
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1819
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Recent Articles
1.
Bulliard M, Pinjusic K, Iacobucci L, Schmuziger C, Fournier N, Constam D
Nat Commun
. 2025 Mar;
16(1):2354.
PMID: 40064965
Receptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin...
2.
Pinjusic K, Bulliard M, Rothe B, Ansaryan S, Liu Y, Ginefra P, et al.
Commun Biol
. 2024 Oct;
7(1):1383.
PMID: 39448726
The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and how it facilitates access to signaling receptors is unclear. Here, analysis...
3.
Pinjusic K, Ambrosini G, Lourenco J, Fournier N, Iseli C, Guex N, et al.
Front Immunol
. 2024 Feb;
14:1335207.
PMID: 38304252
The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells...
4.
Rothe B, Ikawa Y, Zhang Z, Katoh T, Kajikawa E, Minegishi K, et al.
PLoS Biol
. 2023 Sep;
21(9):e3002302.
PMID: 37733651
Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA...
5.
Rothe B, Fortier S, Gagnieux C, Schmuziger C, Constam D
iScience
. 2023 Jun;
26(6):106855.
PMID: 37275520
The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules...
6.
Leitao S, Drake B, Pinjusic K, Pierrat X, Navikas V, Nievergelt A, et al.
ACS Nano
. 2021 Nov;
15(11):17613-17622.
PMID: 34751034
Nanocharacterization plays a vital role in understanding the complex nanoscale organization of cells and organelles. Understanding cellular function requires high-resolution information about how the cellular structures evolve over time. A...
7.
Minegishi K, Rothe B, Komatsu K, Ono H, Ikawa Y, Nishimura H, et al.
Nat Commun
. 2021 Jul;
12(1):4071.
PMID: 34210974
Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown...
8.
Rothe B, Gagnieux C, Leal-Esteban L, Constam D
Cell Signal
. 2019 Dec;
68:109499.
PMID: 31838063
Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein...
9.
Low K, Hardes K, Fedeli C, Seidah N, Constam D, Pasquato A, et al.
FEBS J
. 2019 Jul;
286(22):4597-4620.
PMID: 31276291
The basic proprotein convertases (PCs) furin, PC1/3, PC2, PC5/6, PACE4, PC4, and PC7 are promising drug targets for human diseases. However, developing selective inhibitors remains challenging due to overlapping substrate...
10.