Benjamin Rothe
Overview
Explore the profile of Benjamin Rothe including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
337
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Recent Articles
1.
Pinjusic K, Bulliard M, Rothe B, Ansaryan S, Liu Y, Ginefra P, et al.
Commun Biol
. 2024 Oct;
7(1):1383.
PMID: 39448726
The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and how it facilitates access to signaling receptors is unclear. Here, analysis...
2.
Rothe B, Ikawa Y, Zhang Z, Katoh T, Kajikawa E, Minegishi K, et al.
PLoS Biol
. 2023 Sep;
21(9):e3002302.
PMID: 37733651
Organ laterality of vertebrates is specified by accelerated asymmetric decay of Dand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA...
3.
Rothe B, Fortier S, Gagnieux C, Schmuziger C, Constam D
iScience
. 2023 Jun;
26(6):106855.
PMID: 37275520
The growing number of diseases linked to aberrant phase transitioning of ribonucleoproteins highlights the need to uncover how the interplay between multivalent protein and RNA interactions is regulated. Cytoplasmic granules...
4.
Minegishi K, Rothe B, Komatsu K, Ono H, Ikawa Y, Nishimura H, et al.
Nat Commun
. 2021 Jul;
12(1):4071.
PMID: 34210974
Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown...
5.
Bragantini B, Charron C, Bourguet M, Paul A, Tiotiu D, Rothe B, et al.
Nat Commun
. 2021 Mar;
12(1):1859.
PMID: 33767140
Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We...
6.
Rothe B, Gagnieux C, Leal-Esteban L, Constam D
Cell Signal
. 2019 Dec;
68:109499.
PMID: 31838063
Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein...
7.
Chagot M, Quinternet M, Rothe B, Charpentier B, Coutant J, Manival X, et al.
Biochimie
. 2019 Mar;
164:70-82.
PMID: 30914254
Non-coding RNAs associate with proteins to form ribonucleoproteins (RNPs), such as ribosome, box C/D snoRNPs, H/ACA snoRNPs, ribonuclease P, telomerase and spliceosome to ensure cell viability. The assembly of these...
8.
Leal-Esteban L, Rothe B, Fortier S, Isenschmid M, Constam D
PLoS Genet
. 2018 Jul;
14(7):e1007487.
PMID: 29995892
Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or...
9.
Rothe B, Leettola C, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, et al.
Structure
. 2018 Jan;
26(2):209-224.e6.
PMID: 29290488
Head-to-tail polymers of sterile alpha motifs (SAM) can scaffold large macromolecular complexes. Several SAM-domain proteins that bind each other are mutated in patients with cystic kidneys or laterality defects, including...
10.
Rothe B, Manival X, Rolland N, Charron C, Senty-Segault V, Branlant C, et al.
Nucleic Acids Res
. 2017 May;
45(12):7455-7473.
PMID: 28505348
The U3 box C/D snoRNA is one key element of 90S pre-ribosome. It contains a 5΄ domain pairing with pre-rRNA and the U3B/C and U3C΄/D motifs for U3 packaging into...