Daniel Alpern
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Explore the profile of Daniel Alpern including associated specialties, affiliations and a list of published articles.
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15
Citations
757
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Recent Articles
1.
Ferrero R, Rainer P, Rumpler M, Russeil J, Zachara M, Pezoldt J, et al.
Cell Metab
. 2024 May;
36(7):1566-1585.e9.
PMID: 38729152
Adipose tissue plasticity is orchestrated by molecularly and functionally diverse cells within the stromal vascular fraction (SVF). Although several mouse and human adipose SVF cellular subpopulations have by now been...
2.
Boder-Pasche S, Demir M, Heub S, Garzuel M, Ischer R, Migliozzi D, et al.
Biomed Microdevices
. 2024 Feb;
26(2):18.
PMID: 38416278
High-throughput transcriptomics is of increasing fundamental biological and clinical interest. The generation of molecular data from large collections of samples, such as biobanks and drug libraries, is boosting the development...
3.
Zachara M, Rainer P, Hashimi H, Russeil J, Alpern D, Ferrero R, et al.
EMBO J
. 2022 Aug;
41(18):e108206.
PMID: 35996853
Adipose stem and precursor cells (ASPCs) give rise to adipocytes and determine the composition and plasticity of adipose tissue. Recently, several studies have demonstrated that ASPCs partition into at least...
4.
Fuertes Marraco S, Alpern D, Lofek S, Lourenco J, Bovay A, Maby-El Hajjami H, et al.
Curr Res Immunol
. 2022 May;
3:1-12.
PMID: 35496820
CD8 T cells have multiple functional properties that mediate acute phase and long-term immune protection. Several effector and memory CD8 T cell subsets have been described with diverse functionalities and...
5.
Llimos G, Gardeux V, Koch U, Kribelbauer J, Hafner A, Alpern D, et al.
Nat Commun
. 2022 Apr;
13(1):2042.
PMID: 35440565
Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a conceptual...
6.
Vkovski P, Gultom M, Kelly J, Steiner S, Russeil J, Mangeat B, et al.
PLoS Biol
. 2021 Mar;
19(3):e3001158.
PMID: 33780434
Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV,...
7.
Kaya-Copur A, Marchiano F, Hein M, Alpern D, Russeil J, Luis N, et al.
Elife
. 2021 Jan;
10.
PMID: 33404503
Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth....
8.
Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, et al.
Sci Rep
. 2020 Oct;
10(1):18308.
PMID: 33110158
Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatology...
9.
Dainese R, Gardeux V, Llimos G, Alpern D, Jiang J, Meireles-Filho A, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(24):13828-13838.
PMID: 32461370
Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular...
10.
Alpern D, Gardeux V, Russeil J, Mangeat B, Meireles-Filho A, Breysse R, et al.
Genome Biol
. 2019 Apr;
20(1):71.
PMID: 30999927
Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as the default gene expression analysis method. We present a novel approach, BRB-seq, which uses early...