Dane D Jensen
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Explore the profile of Dane D Jensen including associated specialties, affiliations and a list of published articles.
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27
Citations
881
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Recent Articles
1.
Bhansali D, Tu N, Inoue K, Teng S, Li T, Tran H, et al.
Biomaterials
. 2024 Oct;
314:122874.
PMID: 39418848
Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR is a G...
2.
Bhansali D, Akinade T, Li T, Zhong Y, Liu F, Huang H, et al.
Pharmaceutics
. 2024 Jan;
16(1).
PMID: 38276488
Conventionally, nanocarriers are used to regulate the controlled release of therapeutic payloads. Increasingly, they can also be designed to have an intrinsic therapeutic effect. For example, a positively charged nanocarrier...
3.
Santi M, Zhang M, Liu N, Viet C, Xie T, Jensen D, et al.
Pharmaceuticals (Basel)
. 2023 Nov;
16(11).
PMID: 38004424
Oral cancer pain remains a significant public health concern. Despite the development of improved treatments, pain continues to be a debilitating clinical feature of the disease, leading to reduced oral...
4.
Hegron A, Peach C, Tonello R, Seemann P, Teng S, Latorre R, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(22):e2220979120.
PMID: 37216510
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonists...
5.
Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2
Xie Y, Fontenot L, Chupina Estrada A, Nelson B, Wang J, Shih D, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Jul;
14(4):841-876.
PMID: 35840034
Background & Aims: More than half of Crohn's disease patients develop intestinal fibrosis-induced intestinal strictures. Elafin is a human protease inhibitor that is down-regulated in the stricturing intestine of Crohn's...
6.
Latorre R, Ramirez-Garcia P, Hegron A, Grace J, Retamal J, Shenoy P, et al.
Biomaterials
. 2022 May;
285:121536.
PMID: 35533442
Soft polymer nanoparticles designed to disassemble and release an antagonist of the neurokinin 1 receptor (NKR) in endosomes provide efficacious yet transient relief from chronic pain. These micellar nanoparticles are...
7.
De Logu F, Nassini R, Hegron A, Landini L, Jensen D, Latorre R, et al.
Nat Commun
. 2022 Feb;
13(1):646.
PMID: 35115501
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism...
8.
Latorre R, Hegron A, Peach C, Teng S, Tonello R, Retamal J, et al.
Proc Natl Acad Sci U S A
. 2022 Feb;
119(6).
PMID: 35110404
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated...
9.
Tu N, Inoue K, Chen E, Anderson B, Sawicki C, Scheff N, et al.
Cancers (Basel)
. 2021 Sep;
13(18.
PMID: 34572924
Oral squamous cell carcinoma (SCC) pain is more prevalent and severe than pain generated by any other form of cancer. We previously showed that protease-activated receptor-2 (PAR) contributes to oral...
10.
Jimenez-Vargas N, Yu Y, Jensen D, Bok D, Wisdom M, Latorre R, et al.
Gut
. 2021 Mar;
71(4):695-704.
PMID: 33785555
Objective: The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide...