Dan R Littman
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Explore the profile of Dan R Littman including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Thompson K, Bonham K, Ilott N, Britton G, Colmenero P, Bullers S, et al.
Sci Transl Med
. 2023 Jul;
15(706):eabn4722.
PMID: 37494472
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which...
12.
Larson J, Jin S, Loschi M, Bolivar Wagers S, Thangavelu G, Zaiken M, et al.
Am J Transplant
. 2023 Mar;
23(8):1102-1115.
PMID: 36878433
Damage to the gastrointestinal tract following allogeneic hematopoietic stem cell transplantation is a significant contributor to the severity and perpetuation of graft-versus-host disease. In preclinical models and clinical trials, we...
13.
Zhang B, Upadhyay R, Hao Y, Samanovic M, Herati R, Blair J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747786
The human immune response to SARS-CoV-2 antigen after infection or vaccination is defined by the durable production of antibodies and T cells. Population-based monitoring typically focuses on antibody titer, but...
14.
Schnell A, Littman D, Kuchroo V
Nat Immunol
. 2023 Jan;
24(1):19-29.
PMID: 36596896
Since their discovery almost two decades ago, interleukin-17-producing CD4 T cells (T17 cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory disorders. In addition, T17 cells have...
15.
Bernard-Raichon L, Venzon M, Klein J, Axelrad J, Zhang C, Sullivan A, et al.
Nat Commun
. 2022 Nov;
13(1):5926.
PMID: 36319618
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis...
16.
Upadhyay R, Littman D
Sci Transl Med
. 2022 Oct;
14(668):eadd3901.
PMID: 36288277
An arthritogenic strain of in the gut elicits a local immune response, a precursor to systemic autoimmunity (Chriswell ).
17.
Hall J, Pokrovskii M, Kroehling L, Kim B, Kim S, Wu L, et al.
Immunity
. 2022 Oct;
55(11):2027-2043.e9.
PMID: 36243007
T helper 17 (Th17) cells regulate mucosal barrier defenses but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17 cell differentiation have been elucidated, the transcriptional programs that...
18.
Kedmi R, Najar T, Mesa K, Grayson A, Kroehling L, Hao Y, et al.
Nature
. 2022 Sep;
610(7931):E7.
PMID: 36151471
No abstract available.
19.
Kedmi R, Najar T, Mesa K, Grayson A, Kroehling L, Hao Y, et al.
Nature
. 2022 Sep;
610(7933):737-743.
PMID: 36071167
The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment. The consequences...
20.
Teghanemt A, Pulipati P, Misel-Wuchter K, Day K, Yorek M, Yi R, et al.
Nat Commun
. 2022 Mar;
13(1):1477.
PMID: 35304452
The epigenetic patterns that are established during early thymic development might determine mature T cell physiology and function, but the molecular basis and topography of the genetic elements involved are...