Dachun Liu
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Explore the profile of Dachun Liu including associated specialties, affiliations and a list of published articles.
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26
Citations
384
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Recent Articles
1.
Rago A, Zoi I, Gartman J, McDaniel K, Jana N, Liu D, et al.
J Med Chem
. 2024 Jul;
67(15):13174-13186.
PMID: 39051635
Exploring the scope of biocatalytic transformations in the absence of enzyme structures without extensive experimentation is a challenging task. To expand the limited substrate capacity of carrot-mediated bioreduction and hunt...
2.
Deng P, Li L, Liu D, Chen X, Jiang W
Phys Chem Chem Phys
. 2021 Sep;
23(37):21218-21226.
PMID: 34542142
The adsorption and dissociation of phosgene (COCl) molecules on three kinds of rutile TiO(110) surfaces (stoichiometric: TiO-Sto; oxygen defective: TiO-Ov; and substoichiometric: TiO) were investigated based on density functional theory...
3.
Sheppard G, Wang L, Fidanze S, Hasvold L, Liu D, Pratt J, et al.
J Med Chem
. 2020 Apr;
63(10):5585-5623.
PMID: 32324999
The BET family of proteins consists of BRD2, BRD3, BRD4, and BRDt. Each protein contains two distinct bromodomains (BD1 and BD2). BET family bromodomain inhibitors under clinical development for oncology...
4.
Faivre E, McDaniel K, Albert D, Mantena S, Plotnik J, Wilcox D, et al.
Nature
. 2020 Jan;
578(7794):306-310.
PMID: 31969702
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with...
5.
Wang Z, Zhao Z, Zhang L, Liu F, Peng B, Chai L, et al.
J Hazard Mater
. 2018 Nov;
364:488-498.
PMID: 30388632
The interactions between FeSiO and ZnO play an essential role in the recovery of zinc from copper slag. The dissolution and substitution mechanism of ZnO in fayalite were investigated by...
6.
Lei X, Xu B, Yang G, Shi T, Liu D, Yang B
Mater Sci Eng C Mater Biol Appl
. 2018 Jul;
91:125-134.
PMID: 30033239
A metallurgical material integration concept, using porous calcium titanate (CaTiO) as raw material, was put forward for preparation of metallic titanium powder and porous titanium by calciothermic reduction. Porous metallic...
7.
Fidanze S, Liu D, Mantei R, Hasvold L, Pratt J, Sheppard G, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(10):1804-1810.
PMID: 29678460
Novel conformationally constrained BET bromodomain inhibitors have been developed. These inhibitors were optimized in two similar, yet distinct chemical series, the 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (A) and the 1-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (B). Each series demonstrated...
8.
Wagner R, Randolph J, Patel S, Nelson L, Matulenko M, Keddy R, et al.
J Med Chem
. 2018 Apr;
61(9):4052-4066.
PMID: 29653491
Curative interferon and ribavirin sparing treatments for hepatitis C virus (HCV)-infected patients require a combination of mechanistically orthogonal direct acting antivirals. A shared component of these treatments is usually an...
9.
Randolph J, Krueger A, Donner P, Pratt J, Liu D, Motter C, et al.
J Med Chem
. 2018 Jan;
61(3):1153-1163.
PMID: 29342358
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound...
10.
McDaniel K, Wang L, Soltwedel T, Fidanze S, Hasvold L, Liu D, et al.
J Med Chem
. 2017 Sep;
60(20):8369-8384.
PMID: 28949521
The development of bromodomain and extraterminal domain (BET) bromodomain inhibitors and their examination in clinical studies, particularly in oncology settings, has garnered substantial recent interest. An effort to generate novel...