D W Nebert
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Explore the profile of D W Nebert including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Nebert D, BINGHAM E
Trends Biotechnol
. 2001 Nov;
19(12):519-23.
PMID: 11711196
Pharmacogenomics is the study of the inherited basis of differences in response to drugs. These interindividual differences are often more than tenfold; a 'slow metabolizer' or 'low-responsive' individual might therefore...
12.
Smith A, Clothier B, Carthew P, Childs N, Sinclair P, Nebert D, et al.
Toxicol Appl Pharmacol
. 2001 Jun;
173(2):89-98.
PMID: 11384210
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the liver of C57BL/6J mice is a model for clinical sporadic porphyria cutanea tarda (PCT). There is massive uroporphyria, inhibition of uroporphyrinogen decarboxylase (UROD)...
13.
Sinclair P, Gorman N, Walton H, Bement W, SZAKACS J, Gonzalez F, et al.
Arch Biochem Biophys
. 2001 May;
384(2):383-90.
PMID: 11368328
Porphyria cutanea tarda is a liver disease characterized by excess production of uroporphyrin. We previously reported that acetone, an inducer of CYP2E1, enhances hepatic uroporphyrin accumulation in mice treated with...
14.
Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair P, Sinclair J, et al.
Biochem Pharmacol
. 2001 Mar;
61(7):843-9.
PMID: 11274970
In congenital jaundice, which is due to defects of bilirubin gluruconidation, bilirubin is degraded by an alternative pathway into unidentified products. Previously, it was shown that plasma bilirubin levels can...
15.
Dieter M, Freshwater S, Solis W, Nebert D, Dalton T
Biochem Pharmacol
. 2001 Feb;
61(2):215-25.
PMID: 11163336
To investigate a possible role of phosphorylation in the signal transduction pathways responsible for transcriptional regulation of drug-metabolizing enzymes, we tested seven specific tyrosine kinase inhibitors (tyrphostins) for their effects...
16.
Nebert D
Eur J Pharmacol
. 2001 Jan;
410(2-3):107-120.
PMID: 11134663
Pharmacogenetics represents "the study of variability in drug response due to heredity". Of the more than six dozen pharmacogenetic differences described in the medical literature, the majority of these variations...
17.
Dalton T, Dieter M, Yang Y, Shertzer H, Nebert D
Biochem Biophys Res Commun
. 2000 Dec;
279(2):324-9.
PMID: 11118286
The biosynthesis of reduced glutathione (GSH) is carried out by the enzymes gamma-glutamylcysteine synthetase (GCL) and GSH synthetase. GCL is the rate-limiting step and represents a heterodimeric enzyme comprised of...
18.
Nebert D
Clin Chem Lab Med
. 2000 Nov;
38(9):857-61.
PMID: 11097340
Individual risk of toxicity or cancer reflects the amount of exposure to environmental agents, combined with one's underlying genetic predisposition. More than six dozen human ecogenetic polymorphisms have been described;...
19.
Nebert D, Dalton T, Stuart G, Carvan 3rd M
Ann N Y Acad Sci
. 2000 Nov;
919:148-70.
PMID: 11083106
Genetic differences in environmental toxicity and cancer susceptibility among individuals in a human population often reflect polymorphisms in the genes encoding drug-metabolizing enzymes (DMEs), drug transporters, and receptors that control...
20.
Carvan 3rd M, Dalton T, Stuart G, Nebert D
Ann N Y Acad Sci
. 2000 Nov;
919:133-47.
PMID: 11083105
Using the golden mutant zebrafish having a decrease in interfering pigmentation, we are developing transgenic lines in which DNA motifs that respond to selected environmental pollutants are capable of activating...