D S Singer
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Explore the profile of D S Singer including associated specialties, affiliations and a list of published articles.
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77
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Recent Articles
1.
Giuliani C, Saji M, Bucci I, Fiore G, Liberatore M, Singer D, et al.
J Endocrinol
. 2006 May;
189(3):605-15.
PMID: 16731791
Increased major histocompatibility complex (MHC) class I gene expression in nonimmune cell 'target tissues' involved in organ-specific diseases may be important in the pathogenesis of autoimmune diseases. This possibility in...
2.
Mozes E, Lovchik J, Zinger H, Singer D
Lupus
. 2005 May;
14(4):308-14.
PMID: 15864917
(NZBxNZW)F1 mice spontaneously develop with age an autoimmune disease that resembles the human disease, systemic lupus erythematosus (SLE). Previous studies have demonstrated that susceptibility to experimentally induced SLE depended on...
3.
Gegonne A, Weissman J, Singer D
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12432-7.
PMID: 11592977
The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex....
4.
Weissman J, Hwang J, Singer D
Biochim Biophys Acta
. 2001 Mar;
1546(1):156-63.
PMID: 11257518
The HIV transactivator, Tat, has been shown to be capable of potent repression of transcription initiation. Repression is mediated by the C-terminal segment of Tat, which binds the TFIID component,...
5.
Raval A, Howcroft T, Weissman J, Kirshner S, Zhu X, Yokoyama K, et al.
Mol Cell
. 2001 Feb;
7(1):105-15.
PMID: 11172716
The CIITA coactivator is essential for transcriptional activation of MHC class II genes and mediates enhanced MHC class I transcription. We now report that CIITA contains an intrinsic acetyltransferase (AT)...
6.
Kohn L, Napolitano G, Singer D, Molteni M, Scorza R, Shimojo N, et al.
Int Rev Immunol
. 2000 Dec;
19(6):633-64.
PMID: 11129119
In this report we summarize evidence to support a model for the development of Graves' disease. The model suggests that Graves' disease is initiated by an insult to the thyrocyte...
7.
Napolitano G, Montani V, Giuliani C, Di Vincenzo S, Bucci I, Todisco V, et al.
Mol Endocrinol
. 2000 Apr;
14(4):486-505.
PMID: 10770487
Transforming growth factor (TGF)-beta1-decreased major histocompatibility complex (MHC) class I gene expression in thyrocytes is transcriptional; it involves trans factors and cis elements important for hormone- as well as iodide-regulated...
8.
Weissman J, Howcroft T, Singer D
J Biol Chem
. 2000 Apr;
275(14):10160-7.
PMID: 10744699
TAF(II)250, a component of the general transcription factor, TFIID, is required for the transcription of a subset of genes, including those involved in regulating cell cycle progression. The tsBN462 cell...
9.
Giuliani C, Napolitano G, Mastino A, Di Vincenzo S, Dagostini C, Grelli S, et al.
Eur J Immunol
. 2000 Mar;
30(3):778-86.
PMID: 10741392
In this study we examined the effect of the synthetic peptide thymosin-alpha1 (T(alpha)1) on MHC class I expression in FRTL-5 cells. Treatment with T(alpha)1 increased expression of MHC class I...
10.
Kirshner S, Palmer L, Bodor J, Saji M, Kohn L, Singer D
Mol Endocrinol
. 2000 Jan;
14(1):82-98.
PMID: 10628749
In response to TSH, thyroid cells decrease major histocompatibility (MHC) class I expression and transcription, providing an excellent model for studying the dynamic modulation of transcription of MHC class I...