D S Singer
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Explore the profile of D S Singer including associated specialties, affiliations and a list of published articles.
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77
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1104
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Recent Articles
11.
Singer D, Zinger H, Kohn L, Mozes E
Eur J Immunol
. 1999 Jul;
29(7):2259-68.
PMID: 10427989
Mice deficient in beta2-microglobulin expression are resistant to the induction of experimental systemic lupus erythematosus (SLE). The present studies were designed to identify the beta2-microglobulin-dependent cell surface molecule(s) that confers...
12.
Rodgers J, Levitt J, Cresswell P, Lindahl K, Mathis D, MONACO J, et al.
J Immunol
. 1999 Jun;
162(10):6294.
PMID: 10375304
No abstract available.
13.
Howcroft T, Murphy C, Weissman J, Huber S, Sawadogo M, Singer D
Mol Cell Biol
. 1999 Jun;
19(7):4788-97.
PMID: 10373528
The tissue-specific expression of major histocompatibility complex class I genes is determined by a series of upstream regulatory elements, many of which remain ill defined. We now report that a...
14.
Carroll I, Wang J, Howcroft T, Singer D
Mol Immunol
. 1999 Apr;
35(18):1171-8.
PMID: 10199391
The MHC class I complex, which binds and presents peptide antigen, is composed of a class I heavy chain and the beta2-microglobulin light chain. HIV-1, which induces a profound immunodeficiency...
15.
Suzuki K, Mori A, Ishii K, Saito J, Singer D, Klinman D, et al.
Proc Natl Acad Sci U S A
. 1999 Mar;
96(5):2285-90.
PMID: 10051633
Abnormal expression of major histocompatibility complex (MHC) class I and class II in various tissues is associated with autoimmune disease. Autoimmune responses can be triggered by viral infections or tissue...
16.
Weissman J, Brown J, Howcroft T, Hwang J, Chawla A, Roche P, et al.
Proc Natl Acad Sci U S A
. 1998 Sep;
95(20):11601-6.
PMID: 9751712
HIV Tat, a transactivator of viral transcription, represses transcription of major histocompatibility (MHC) class I genes. Repression depends exclusively on the C-terminal domain of Tat, although the mechanism of this...
17.
Suzuki K, Lavaroni S, Mori A, Ohta M, Saito J, Pietrarelli M, et al.
Proc Natl Acad Sci U S A
. 1998 Jul;
95(14):8251-6.
PMID: 9653173
Thyroglobulin (TG), the primary synthetic product of the thyroid, is the macromolecular precursor of thyroid hormones. TG synthesis, iodination, storage in follicles, and degradation control thyroid hormone formation and secretion...
18.
Suzuki K, Ohta M, Saito J, Ohmori M, Montani V, Napolitano G, et al.
Endocrinology
. 1998 May;
139(5):2300-13.
PMID: 9564838
The single strand binding protein (SSBP-1) is a positive regulator of TSH receptor gene expression and binds to an element with a GXXXXG motif. The S box of the mouse...
19.
Mozes E, Zinger H, Kohn L, Singer D
J Clin Immunol
. 1998 Apr;
18(2):106-13.
PMID: 9533654
(NZB x NZW)F1 mice spontaneously develop with age an autoimmune disease that resembles the human disease, systemic lupus erythematosus (SLE). The present study demonstrates that methimazole (MMI), an agent used...
20.
Rellahan B, Jensen J, Howcroft T, Singer D, Bonvini E, Weissman A
J Immunol
. 1998 Mar;
160(6):2794-801.
PMID: 9510181
In mature T cells, limited synthesis of the TCR-zeta subunit is primarily responsible for regulating surface expression of TCRs. Transcription of zeta is directed by a complex promoter that includes...