D S Sem
Overview
Explore the profile of D S Sem including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
144
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Recent Articles
1.
Schwabe M, Fleischer A, Kuehn R, Chaudhury S, York J, Sem D, et al.
Front Aging Neurosci
. 2024 Dec;
16:1477045.
PMID: 39629477
Introduction: Alzheimer's disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot...
2.
Costache A, Trawick D, Bohl D, Sem D
Xenobiotica
. 2007 Jul;
37(3):221-45.
PMID: 17624022
Organic amines are prevalent in nature and in drugs, especially the psychotherapeutic agents, and a major defense against potentially toxic amines is metabolism by CYP2D6. In order to understand better...
3.
Sem D, Yu L, Coutts S, Jack R
J Cell Biochem Suppl
. 2002 Feb;
Suppl 37:99-105.
PMID: 11842434
As a result of genomics efforts, the number of protein drug targets is expected to increase by an order of magnitude. Functional genomics efforts are identifying these targets, while structural...
4.
Sem D, Pellecchia M
Curr Opin Drug Discov Devel
. 2001 Dec;
4(4):479-92.
PMID: 11727313
The field of NMR spectroscopy has grown beyond expectations from the first historic observation of nuclear magnetic resonance in 1946 by Bloch and Purcell, to the first generation of protein...
5.
Pellecchia M, Meininger D, Shen A, Jack R, Kasper C, Sem D
J Am Chem Soc
. 2001 Jul;
123(19):4633-4.
PMID: 11457263
No abstract available.
6.
Sem D, McNeeley P, Linnik M
Arch Biochem Biophys
. 1999 Nov;
372(1):62-8.
PMID: 10562417
This paper presents the equations and methodology for the measurement and interpretation of apparent dissociation constants for polyclonal populations of antibodies, where antigen is kept trace relative to antibody concentration....
7.
Shen A, Sem D, Kasper C
J Biol Chem
. 1999 Feb;
274(9):5391-8.
PMID: 10026149
Site-directed mutagenesis has been employed to study the mechanism of hydride transfer from NADPH to NADPH-cytochrome P450 oxidoreductase. Specifically, Ser457, Asp675, and Cys630 have been selected because of their proximity...
8.
Sem D, McNeeley P
FEBS Lett
. 1999 Feb;
443(1):17-9.
PMID: 9928944
This paper presents the application of fluorescence polarization to the determination of dissociation constants for competitive inhibitors that bind to enzymes. This steady-state enzyme kinetic study measures the inhibition of...
9.
Sem D, Baker B, Victoria E, Jones D, Marquis D, Yu L, et al.
Biochemistry
. 1998 Nov;
37(46):16069-81.
PMID: 9819200
The presence of high titers of anti-cardiolipin antibodies (ACA's) of autoimmune origin, which are known to bind to plasma beta2-glycoprotein I (aka apolipoprotein H), correlates clinically with autoimmune recurrent thrombosis....
10.
Holmbeck S, Foster M, Casimiro D, Sem D, Dyson H, Wright P
J Mol Biol
. 1998 Aug;
281(2):271-84.
PMID: 9698548
The retinoid X receptor (RXR) is a member of the nuclear hormone receptor superfamily of transcriptional regulators and plays a central role in the retinoid and, through its ability to...