D S Chien
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Explore the profile of D S Chien including associated specialties, affiliations and a list of published articles.
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23
Citations
142
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Recent Articles
1.
Madhu C, Rix P, Nguyen T, Chien D, Woodward D, Tang-Liu D
J Ocul Pharmacol Ther
. 1998 Nov;
14(5):389-99.
PMID: 9811228
The objective of this study was to assess the corneal and scleral permeabilities of natural prostaglandins as well as their prodrugs and analogs through human cornea and sclera in vitro....
2.
Chien D, Tang-Liu D, Woodward D
J Pharm Sci
. 1997 Oct;
86(10):1180-6.
PMID: 9344177
The objective of this study was to identify prostaglandin F2alpha (PGF2alpha) prodrugs that have an optimal ocular absorption profile and therefore could be potentially useful for the treatment of glaucoma....
3.
Acheampong A, Chien D, Lam S, Vekich S, Breau A, Usansky J, et al.
Xenobiotica
. 1996 Oct;
26(10):1035-55.
PMID: 8905918
1. In vitro metabolism of 14C-brimonidine by the rat, rabbit, dog, monkey and human liver fractions was studied to assess any species differences. In vitro metabolism with rabbit liver aldehyde...
4.
Hayakawa E, Chien D, Inagaki K, Yamamoto A, Wang W, Lee V
Pharm Res
. 1992 Jun;
9(6):769-75.
PMID: 1384027
An in vitro model was used to evaluate the conjunctival penetration of three peptides, [D-ala2]metenkephalinamide (YAGFM, MW 647), substance P (MW 1348), and insulin (MW 5778), in comparison with two...
5.
Adams J, Wilcox M, Trousdale M, Chien D, Shimizu R
Cornea
. 1992 May;
11(3):234-41.
PMID: 1587132
The biological effects of four commercially available artificial tear formulations were evaluated using sensitive in vitro techniques. Two of the formulations contained ingredients implicated in cell damage; the other two...
6.
Chien D, Sandri R
Drug Metab Dispos
. 1992 Mar;
20(2):211-7.
PMID: 1352212
Etretinate, a highly lipophilic retinoid, is known to accumulate in the human body with a slow systemic elimination (half-life approximately 100 days) after long-term treatment. Retinoids with high lipophilicity and...
7.
Chien D, Sasaki H, Bundgaard H, Buur A, Lee V
Pharm Res
. 1991 Jun;
8(6):728-33.
PMID: 2062802
The main objective of this study was to investigate how enzymatic lability would affect the extent of corneal and conjunctival penetration of a series of alkyl, cycloalkyl, and aryl ester...
8.
Wang W, Sasaki H, Chien D, Lee V
Curr Eye Res
. 1991 Jun;
10(6):571-9.
PMID: 1680041
The influence of lipophilicity on the conjunctival penetration of beta blockers in the pigmented rabbit was investigated and compared with that on corneal penetration. The beta blockers were hydrophilic sotalol,...
9.
Srivatsa G, Chan M, Chien D, Tobias B
Curr Eye Res
. 1991 Feb;
10(2):127-32.
PMID: 2036804
Proton nuclear magnetic resonance (nmr) spectra of rabbit ocular tissue homogenates (corneal epithelium, conjunctiva and iris ciliary body) and aqueous humor have been recorded for the first time by incorporation...
10.
Chien D, Homsy J, Gluchowski C, Tang-Liu D
Curr Eye Res
. 1990 Nov;
9(11):1051-9.
PMID: 1982760
The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds...