D R Thakker
Overview
Explore the profile of D R Thakker including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
575
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Recent Articles
1.
Fendt M, Schmid S, Thakker D, Jacobson L, Yamamoto R, Mitsukawa K, et al.
Mol Psychiatry
. 2007 Aug;
13(10):970-9.
PMID: 17712315
Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we...
2.
Cryan J, Thakker D, Hoyer D
Biochem Soc Trans
. 2007 Mar;
35(Pt 2):411-5.
PMID: 17371288
Psychiatric and neurological disorders are among the most complex, poorly understood and debilitating diseases in medicine. Abrogating gene function using knockout animals is one of the primary means of examining...
3.
Thakker D, Natt F, Husken D, van der Putten H, Maier R, Hoyer D, et al.
Mol Psychiatry
. 2005 Jun;
10(8):782-9, 714.
PMID: 15940298
Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressant drugs that increase the extracellular levels of serotonin by blocking the reuptake activity of the serotonin transporter (SERT). Although SSRIs elevate...
4.
Thakker D, Standifer K
Neuropharmacology
. 2002 Nov;
43(6):979-90.
PMID: 12423667
The molecular mechanism(s) underlying cross-tolerance between mu and opioid receptor-like 1 (ORL1) receptor agonists were investigated using two human neuroblastoma cell lines endogenously expressing these receptors and G protein-coupled receptor...
5.
Annaert P, Turncliff R, Booth C, Thakker D, Brouwer K
Drug Metab Dispos
. 2001 Sep;
29(10):1277-83.
PMID: 11560870
Recently, sandwich-cultured (SC) rat hepatocytes have been used as an in vitro model to assess biliary excretion of drugs and xenobiotics. The purpose of the present study was to validate...
6.
Liu D, Kucera L, Ishaq K, Thakker D
J Pharm Sci
. 1999 Nov;
88(11):1169-74.
PMID: 10564066
The oral route is the preferred route of delivery for a large number of drug molecules. However, the intestinal epithelium presents a formidable barrier for delivery of drugs into systemic...
7.
Liu D, LeCluyse E, Thakker D
J Pharm Sci
. 1999 Nov;
88(11):1161-8.
PMID: 10564065
The intestinal epithelium is a significant barrier for oral absorption of hydrophilic drugs because they cannot easily traverse the lipid bilayer of the cell membrane and their passage through the...
8.
Lee K, Thakker D
J Pharm Sci
. 1999 Jul;
88(7):680-7.
PMID: 10393565
The purpose of this study was to investigate the mechanism by which the H2-antagonists ranitidine and famotidine interacted with the paracellular space during their transport across Caco-2 cell monolayers. Transport...
9.
Gan L, Yanni S, Thakker D
Pharm Res
. 1998 Mar;
15(1):53-7.
PMID: 9487546
Purpose: The tight junctions in the intestinal epithelium represent highly specialized intercellular junctions. Ranitidine, an H2-antagonist, causes a tightening of the tight junctions. Hence, we have investigated the effect of...
10.
Kang S, Sinhababu A, CORY J, Mitchell B, Thakker D, Cho M
Pharm Res
. 1997 Jun;
14(6):706-12.
PMID: 9210185
Purpose: This study is concerned with cellular delivery/generation of 2'-azido-2'-deoxyuridine and -deoxycytidine diphosphate (N3UDP or N3CDP), potent inhibitors of ribonucleotide reductase. It characterizes the phosphorylation steps involved in the conversion...