D R Petersen
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Explore the profile of D R Petersen including associated specialties, affiliations and a list of published articles.
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79
Citations
843
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Recent Articles
11.
Tjalkens R, COOK L, Petersen D
Arch Biochem Biophys
. 1999 Jan;
361(1):113-9.
PMID: 9882435
The cellular metabolism of 4-hydroxy-2-nonenal (4-HNE), a cytotoxic and genotoxic product of oxidative stress-induced lipid peroxidation, was investigated in rat H35 hepatoma cells. Previous studies from our laboratory (1) have...
12.
Tjalkens R, Luckey S, Kroll D, Petersen D
Arch Biochem Biophys
. 1998 Nov;
359(1):42-50.
PMID: 9799558
A series of alpha,beta-unsaturated aldehydes was evaluated to determine if these compounds could mediate inducible expression of glutathione S-transferase (GST) through the 5'-flanking antioxidant response element (ARE). The ARE from...
13.
Valerio Jr L, Petersen D
Toxicol Lett
. 1998 Oct;
98(1-2):31-9.
PMID: 9776559
Lipid peroxidation has been proposed to be a major mechanism involved in the pathophysiology of hepatic iron overload. Hepatic microsomal lipid peroxidation has been demonstrated in animals with dietary iron...
14.
Tjalkens R, Valerio Jr L, Awasthi Y, Petersen D
Toxicol Appl Pharmacol
. 1998 Aug;
151(1):174-81.
PMID: 9705901
The alpha-class glutathione S-transferases are proposed to play a prominent role in catalyzing the conjugation of glutathione with electrophilic aldehydic products of lipid peroxidation. The effect of iron-induced lipid peroxidation...
15.
Hartley D, Kroll D, Petersen D
Chem Res Toxicol
. 1997 Aug;
10(8):895-905.
PMID: 9282839
Toxicity associated with prooxidant-mediated hepatic lipid peroxidation is postulated to originate from the interaction of the aldehydic end products of lipid peroxidation with cellular constituents. The principal alpha,beta-unsaturated aldehydic products...
16.
Hartley D, Petersen D
Alcohol Clin Exp Res
. 1997 Apr;
21(2):298-304.
PMID: 9113267
Our laboratory has previously reported on the ability of 4-hydroxynonenal (4-HNE), a primary product of lipid peroxidation, to inhibit acetaldehyde metabolism in isolated mouse liver mitochondria. The purpose of the...
17.
18.
Valerio Jr L, Parks T, Petersen D
Alcohol Clin Exp Res
. 1996 Nov;
20(8):1352-61.
PMID: 8947310
The notion that prolonged ethanol consumption promotes hepatocellular damage through interactions with iron was evaluated in rats fed ethanol with or without supplemental dietary carbonyl iron. The individual and combined...
19.
Khan M, Srivastava S, SINGHAL S, Chaubey M, Awasthi S, Petersen D, et al.
Toxicol Appl Pharmacol
. 1995 Mar;
131(1):63-72.
PMID: 7878679
Since previous studies from this laboratory have suggested that glutathione S-transferase (GST) 8-8 of rat belongs to a distinct subgroup of GST isozymes which may be involved in the detoxification...
20.
Hartley D, Ruth J, Petersen D
Arch Biochem Biophys
. 1995 Jan;
316(1):197-205.
PMID: 7840616
It has previously been reported that isolated rat hepatocytes rapidly and completely metabolize high concentrations of 4-hydroxy-2,3-(E)-nonenal (4-HNE). However, until this report, the degree to which oxidative-reductive and nonoxidative metabolic...