D R Gewert
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Explore the profile of D R Gewert including associated specialties, affiliations and a list of published articles.
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30
Citations
446
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Recent Articles
1.
Deonarain R, Alcami A, Alexiou M, Dallman M, Gewert D, Porter A
J Virol
. 2000 Mar;
74(7):3404-9.
PMID: 10708458
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha...
2.
Yeow W, Au W, Juang Y, FIELDS C, Dent C, Gewert D, et al.
J Biol Chem
. 2000 Feb;
275(9):6313-20.
PMID: 10692430
Type I interferons constitute an important part of the innate immune response against viral infection. Unlike the expression of interferon (IFN) B gene, the expression of IFNA genes is restricted...
3.
Sharp T, Raine D, Gewert D, Joshi B, Jagus R, Clemens M
Virology
. 1999 May;
257(2):303-13.
PMID: 10329541
The 2'-5' oligoadenylate synthetases and the protein kinase PKR are both interferon-induced, double-stranded RNA-dependent proteins that play important roles in the antiviral effects of the interferons and in cellular growth...
4.
Dent C, Gewert D
Eur J Biochem
. 1996 Mar;
236(3):895-903.
PMID: 8665911
Type-I interferons are encoded by a multigene family, the major members of which are at least 13 IFN A subtypes and a single IFN B gene. IFNs A and B...
5.
Dent C, Macbride S, Sharp N, Gewert D
J Interferon Cytokine Res
. 1996 Feb;
16(2):99-107.
PMID: 8742362
This paper addresses the role of transcriptional regulation in the determination of the levels of expression of different interferon-alpha subtypes secreted from Namalwa cells following infection with Sendai virus. Using...
6.
Sharp T, Xiao Q, Justesen J, Gewert D, Clemens M
Eur J Biochem
. 1995 May;
230(1):97-103.
PMID: 7541351
The interferon-inducible double-stranded RNA-dependent protein kinase PKR has been suggested to function as a tumour suppressor gene product. Catalytically inactive mutants of PKR give rise to a tumorigenic phenotype when...
7.
Gewert D, Sharp N, Barber K, Cooper H, Tucker D, Lewis A, et al.
J Interferon Cytokine Res
. 1995 May;
15(5):403-6.
PMID: 7648441
We have analyzed human donor DNA for the presence of sequences corresponding to allelic variants of the IFN-alpha 2 locus. Using both restriction enzyme digestion of PCR-amplified fragments and sequence...
8.
Lewis A, Sims M, Gewert D, Peakman T, Spence H, Crowe J
Nucleic Acids Res
. 1994 Jul;
22(14):2859-61.
PMID: 7519771
No abstract available.
9.
Crowe J, Gewert D, Barber K, Lewis A, Sims M, Davies S, et al.
J Infect Dis
. 1994 Apr;
169(4):875-8.
PMID: 8133104
Sixteen Chinese chronic hepatitis B virus (HBV)-infected patients were treated with recombinant interferon-alpha 2a (rIFN-alpha 2a). Of these, 8 made a response to IFN, with titers of neutralizing antibody of...
10.
Peakman T, Worden J, Harris R, Cooper H, Tite J, Page M, et al.
Hum Antibodies Hybridomas
. 1994 Jan;
5(1-2):65-74.
PMID: 7532024
We report a detailed comparison of two commonly used stable, amplifiable mammalian expression systems (Chinese Hamster Ovary cells/dihydrofolate reductase and Mouse NSO myeloma/glutamine synthetase) used to express a humanized IgG1...