Impaired Antiviral Response and Alpha/beta Interferon Induction in Mice Lacking Beta Interferon

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2000 Mar 9

PMID 10708458

Citations 79

Authors

R Deonarain

A Alcami

M Alexiou

M J Dallman

D R Gewert

A C Porter

Affiliations

Soon will be listed here.

Abstract

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

Citing Articles

Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner.

Shuster M, Lyu Z, Augenstreich J, Mathur S, Ganesh A, Ling J Infect Immun. 2024; 92(10):e0009824.

PMID: 39269166 PMC: 11475681. DOI: 10.1128/iai.00098-24.

Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner.

Shuster M, Lyu Z, Augenstreich J, Mathur S, Ganesh A, Ling J bioRxiv. 2024; .

PMID: 38496427 PMC: 10942315. DOI: 10.1101/2024.03.05.583530.

DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response.

Jiao H, James S, Png C, Cui C, Li H, Li L Cell Death Differ. 2024; 31(3):280-291.

PMID: 38383887 PMC: 10923883. DOI: 10.1038/s41418-024-01269-7.

Bee Venom and Its Two Main Components-Melittin and Phospholipase A2-As Promising Antiviral Drug Candidates.

Yaacoub C, Wehbe R, Roufayel R, Fajloun Z, Coutard B Pathogens. 2023; 12(11).

PMID: 38003818 PMC: 10674158. DOI: 10.3390/pathogens12111354.

inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.

Allen C, Banks D, Shuster M, Vogel S, OConnor T, Briken V Infect Immun. 2023; 91(11):e0036523.

PMID: 37843413 PMC: 10652965. DOI: 10.1128/iai.00365-23.

References

Erlandsson L, Blumenthal R, Eloranta M, Engel H, Alm G, Weiss S . Interferon-beta is required for interferon-alpha production in mouse fibroblasts. Curr Biol. 1998; 8(4):223-6. DOI: 10.1016/s0960-9822(98)70086-7. View

Domanski P, Nadeau O, Platanias L, Fish E, Kellum M, Pitha P . Differential use of the betaL subunit of the type I interferon (IFN) receptor determines signaling specificity for IFNalpha2 and IFNbeta. J Biol Chem. 1998; 273(6):3144-7. DOI: 10.1074/jbc.273.6.3144. View

Sato M, Tanaka N, Hata N, Oda E, Taniguchi T . Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene. FEBS Lett. 1998; 425(1):112-6. DOI: 10.1016/s0014-5793(98)00210-5. View

Lin R, Heylbroeck C, Pitha P, Hiscott J . Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998; 18(5):2986-96. PMC: 110678. DOI: 10.1128/MCB.18.5.2986. View

Wathelet M, Lin C, Parekh B, Ronco L, Howley P, Maniatis T . Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell. 1998; 1(4):507-18. DOI: 10.1016/s1097-2765(00)80051-9. View

Naramura M, Hu R, Gu H . Mice with a fluorescent marker for interleukin 2 gene activation. Immunity. 1998; 9(2):209-16. DOI: 10.1016/s1074-7613(00)80603-2. View

Riviere I, Sunshine M, Littman D . Regulation of IL-4 expression by activation of individual alleles. Immunity. 1998; 9(2):217-28. DOI: 10.1016/s1074-7613(00)80604-4. View

Godwin A, Stadler H, Nakamura K, Capecchi M . Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998; 95(22):13042-7. PMC: 23702. DOI: 10.1073/pnas.95.22.13042. View

Marie I, Durbin J, Levy D . Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 1998; 17(22):6660-9. PMC: 1171011. DOI: 10.1093/emboj/17.22.6660. View

10.

Der S, Zhou A, Williams B, Silverman R . Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A. 1998; 95(26):15623-8. PMC: 28094. DOI: 10.1073/pnas.95.26.15623. View

11.

Platanias L, Domanski P, Nadeau O, Yi T, Uddin S, Fish E . Identification of a domain in the beta subunit of the type I interferon (IFN) receptor that exhibits a negative regulatory effect in the growth inhibitory action of type I IFNs. J Biol Chem. 1998; 273(10):5577-81. DOI: 10.1074/jbc.273.10.5577. View

12.

Billiau A, Joniau M, DE SOMER P . Mass production of human interferon in diploid cells stimulated by poly-I:C. J Gen Virol. 1973; 19(1):1-8. DOI: 10.1099/0022-1317-19-1-1. View

13.

Suzuki F, Ishida N, Suzuki M, Sato T, Suzuki S . Effect of the interferon inducer, dextran phosphate, on influenza virus infection in mice. Proc Soc Exp Biol Med. 1975; 149(4):1069-75. DOI: 10.3181/00379727-149-38960. View

14.

Kelley K, Pitha P . Characterization of a mouse interferon gene locus I. Isolation of a cluster of four alpha interferon genes. Nucleic Acids Res. 1985; 13(3):805-23. PMC: 341036. DOI: 10.1093/nar/13.3.805. View

15.

Kelley K, Raj N, Kellum M, Pitha P . Synthesis of fusion and mature murine alpha interferons in Escherichia coli. Gene. 1986; 45(3):317-25. DOI: 10.1016/0378-1119(86)90030-2. View

16.

Dron M, Lacasa M, Tovey M . Priming affects the activity of a specific region of the promoter of the human beta interferon gene. Mol Cell Biol. 1990; 10(2):854-8. PMC: 360890. DOI: 10.1128/mcb.10.2.854-858.1990. View

17.

Asano M, Hayashi M, Yoshida E, KAWADE Y, Iwakura Y . Induction of interferon-alpha by interferon-beta, but not of interferon-beta by interferon-alpha, in the mouse. Virology. 1990; 176(1):30-8. DOI: 10.1016/0042-6822(90)90227-i. View

18.

Pilon M, Gullberg M, Lundgren E . Transient expression of the CD2 cell surface antigen as a sortable marker to monitor high frequency transfection of human primary B cells. J Immunol. 1991; 146(3):1047-51. View

19.

Samuel C . Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology. 1991; 183(1):1-11. DOI: 10.1016/0042-6822(91)90112-o. View

20.

Gobl A, Cederblad B, Sandberg K, Alm G . Interferon-alpha but not -beta genes require de novo protein synthesis for efficient expression in human monocytes. Scand J Immunol. 1992; 35(2):177-85. DOI: 10.1111/j.1365-3083.1992.tb02848.x. View