D N Brindley
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Explore the profile of D N Brindley including associated specialties, affiliations and a list of published articles.
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174
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2558
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Recent Articles
1.
Kerage D, Brindley D, Hemmings D
Placenta
. 2014 Jan;
35 Suppl:S86-92.
PMID: 24411702
Endothelial dysfunction leading to increased vascular tone is implicated in the pathogenesis of cardiovascular disease, hypertension and pregnancy-related complications like preeclampsia and intrauterine growth restriction. Vascular tone is regulated by...
2.
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
Samadi N, Gaetano C, Goping I, Brindley D
Oncogene
. 2008 Dec;
28(7):1028-39.
PMID: 19079345
Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis. ATX converts extracellular lysophosphatidylcholine (LPC) into lysophosphatidate (LPA). As these lipids have been reported to affect cell signaling through...
3.
Mei J, Wang C, OBrien L, Brindley D
Int J Obes Relat Metab Disord
. 2003 Jan;
27(1):31-9.
PMID: 12532151
Objective: To investigate mechanisms for the regulation of glucose incorporation into triacylgycerols in adipocytes by ceramides, which mediate some actions of tumour necrosis factor-alpha (TNFalpha). Design: The effects of C(2)-...
4.
Hanna A, Xu J, Brindley D
Adv Exp Med Biol
. 2002 Mar;
498:191-200.
PMID: 11900368
No abstract available.
5.
Mantha L, Russell J, Brindley D, Deshaies Y
Int J Obes Relat Metab Disord
. 2002 Mar;
26(3):308-17.
PMID: 11896485
Objective: To characterize the developmental changes in adipose and muscle lipoprotein lipase (LPL) activity in the atherosclerosis-prone JCR:LA-corpulent rat, and to test the hypothesis that tissue-specific abnormalities in LPL activity...
6.
Pilquil C, Ling Z, Singh I, BURI K, Zhang Q, Brindley D
Biochem Soc Trans
. 2001 Nov;
29(Pt 6):825-30.
PMID: 11709082
The serum-derived lipid growth factors, lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P), activate cells selectively through different members of a family of endothelial differentiation gene (EDG) receptors. Activation of EDG receptors...
7.
Hanna A, Berthiaume L, Kikuchi Y, Begg D, Bourgoin S, Brindley D
Mol Biol Cell
. 2001 Nov;
12(11):3618-30.
PMID: 11694593
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that activates several signaling cascades. We determined the extent to which ceramide is a second messenger for TNF-alpha-induced signaling leading to cytoskeletal...
8.
Singh I, Stromberg L, Bourgoin S, Sciorra V, Morris A, Brindley D
Biochemistry
. 2001 Sep;
40(37):11227-33.
PMID: 11551222
Ceramides inhibit phospholipase D (PLD) activity in several mammalian cell types. These effects have been related to preventing activation by ARF1, RhoA, and protein kinase C-alpha and -beta and therefore...
9.
Pilquil C, Singh I, Zhang Q, Ling Z, BURI K, Stromberg L, et al.
Prostaglandins Other Lipid Mediat
. 2001 Apr;
64(1-4):83-92.
PMID: 11324709
The serum-derived phospholipid growth factor, lysophosphatidate (LPA), activates cells through a family of G-protein-coupled EDG receptors. The present article examines the role of lipid phosphate phosphatase-1 (LPP-1, or phosphatidate phosphate...
10.
English D, Garcia J, Brindley D
Cardiovasc Res
. 2001 Feb;
49(3):588-99.
PMID: 11166272
Considerable attention has focused on identifying mediators of neovascularization at sites of growth and abnormal tissue development. By contrast, mediators of angiogenesis at sites of injury and wound repair are...