D M Cyr
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Explore the profile of D M Cyr including associated specialties, affiliations and a list of published articles.
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32
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2073
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Recent Articles
1.
Hohfeld J, Cyr D, Patterson C
EMBO Rep
. 2001 Oct;
2(10):885-90.
PMID: 11600451
Molecular chaperones are known to facilitate cellular protein folding. They bind non-native proteins and orchestrate the folding process in conjunction with regulatory cofactors that modulate the affinity of the chaperone...
2.
Jiang J, Ballinger C, Wu Y, Dai Q, Cyr D, Hohfeld J, et al.
J Biol Chem
. 2001 Sep;
276(46):42938-44.
PMID: 11557750
Proper folding of proteins (either newly synthesized or damaged in response to a stressful event) occurs in a highly regulated fashion. Cytosolic chaperones such as Hsc/Hsp70 are assisted by cofactors...
3.
MEACHAM G, Patterson C, Zhang W, Younger J, Cyr D
Nat Cell Biol
. 2001 Jan;
3(1):100-5.
PMID: 11146634
The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient. Most nascent CFTR is retained in the endoplasmic reticulum and...
4.
Gall W, Higginbotham M, Chen C, Ingram M, Cyr D, Graham T
Curr Biol
. 2000 Nov;
10(21):1349-58.
PMID: 11084334
Background: In eukaryotic cells, clathrin-coated vesicles transport specific cargo from the plasma membrane and trans-Golgi network to the endosomal system. Removal of the clathrin coat in vitro requires the uncoating...
5.
Sha B, Lee S, Cyr D
Structure
. 2000 Sep;
8(8):799-807.
PMID: 10997899
Background: Molecular chaperone Hsp40 can bind non-native polypeptide and facilitate Hsp70 in protein refolding. How Hsp40 and other chaperones distinguish between the folded and unfolded states of proteins to bind...
6.
MEACHAM G, Browne B, Zhang W, Kellermayer R, Bedwell D, Cyr D
J Biol Chem
. 1999 Nov;
274(48):34396-402.
PMID: 10567418
The heat shock protein (Hsp) 70/Hsp40 chaperone system plays an essential role in cell physiology, but few of its in vivo functions are known. We report that biogenesis of Axl1p,...
7.
MEACHAM G, Lu Z, King S, Sorscher E, Tousson A, Cyr D
EMBO J
. 1999 Mar;
18(6):1492-505.
PMID: 10075921
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel constructed from two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBD) and a regulatory (R) domain. The NBDs and...
8.
Liu J, Kuo S, Makhov A, Cyr D, Griffith J, Broker T, et al.
J Biol Chem
. 1998 Nov;
273(46):30704-12.
PMID: 9804845
Human papillomavirus replication initiator, the E1 helicase, binds weakly to the origin of DNA replication. Purified human chaperone proteins Hsp70 and Hsp40 (HDJ-1 and HDJ-2) independently and additively enhanced E1...
9.
Lu Z, Cyr D
J Biol Chem
. 1998 Oct;
273(43):27824-30.
PMID: 9774392
Specification of Hsp70 action in cellular protein metabolism may occur through the formation of specialized Hsp70:Hsp40 pairs. To test this model, we compared the ability of purified Sis1 and Ydj1...
10.
Lu Z, Cyr D
J Biol Chem
. 1998 Apr;
273(10):5970-8.
PMID: 9488737
Ydj1 is a member of the Hsp40 (DnaJ-related) chaperone family that facilitates cellular protein folding by regulating Hsp70 ATPase activity and binding unfolded polypeptides. Ydj1 contains four conserved subdomains that...