W Neupert
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Explore the profile of W Neupert including associated specialties, affiliations and a list of published articles.
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298
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10340
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Recent Articles
1.
Mokranjac D, Neupert W
Biochem Soc Trans
. 2005 Oct;
33(Pt 5):1019-23.
PMID: 16246036
Mitochondria comprise approx. 1000-3000 different proteins, almost all of which must be imported from the cytosol into the organelle. So far, six complex molecular machines, protein translocases, were identified that...
2.
Junker J, Hell K, Schlierf M, Neupert W, Rief M
Biophys J
. 2005 Sep;
89(5):L46-8.
PMID: 16183885
We investigated the effect of substrate binding on the mechanical stability of mouse dihydrofolate reductase using single-molecule force spectroscopy by atomic force microscopy. We find that under mechanical forces dihydrofolate...
3.
The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2
Tries S, Neupert W, Laufer S
Inflamm Res
. 2002 May;
51(3):135-43.
PMID: 12005204
Objective: We examined the effects of ML3000 and several non-steroidal antiinflammatory drugs (NSAIDs) on the synthesis of products of 5-LOX (LTB4, LTC4) and COX-1/2 (TXB2, PGE2) in vitro and ex...
4.
Paschen S, Neupert W
IUBMB Life
. 2002 Jan;
52(3-5):101-12.
PMID: 11798021
Most mitochondrial proteins are encoded by the nuclear genome and thus have to be imported into mitochondria from the cytosol. Protein translocation across and into the mitochondrial membranes is a...
5.
Diekert K, de Kroon A, Ahting U, Niggemeyer B, Neupert W, de Kruijff B, et al.
EMBO J
. 2001 Oct;
20(20):5626-35.
PMID: 11598006
The import of proteins into the mitochondrial intermembrane space differs in various aspects from the classical import pathway into the matrix. Apocytochrome c defines one of several pathways known to...
6.
Rothbauer U, Hofmann S, Muhlenbein N, Paschen S, Gerbitz K, Neupert W, et al.
J Biol Chem
. 2001 Aug;
276(40):37327-34.
PMID: 11489896
Tim8 and Tim13 of yeast belong to a family of evolutionary conserved zinc finger proteins that are organized in hetero-oligomeric complexes in the mitochondrial intermembrane space. Mutations in DDP1 (deafness...
7.
Weidner S, Neupert W, Goppelt-Struebe M, Rupprecht H
Arthritis Rheum
. 2001 Jul;
44(7):1698-706.
PMID: 11465722
Objective: Antineutrophil cytoplasmic antibodies (ANCA) are believed to play a pathogenetic role in necrotizing small-vessel vasculitis. While the involvement of neutrophils in this disease has been extensively studied in vitro,...
8.
Bauer M, Neupert W
J Inherit Metab Dis
. 2001 Jun;
24(2):166-80.
PMID: 11405338
The vast majority of mitochondrial proteins are encoded as precursors by the nuclear genome. A major aspect of mitochondrial biogenesis is therefore the transfer of nuclear-encoded, cytosplasmically synthesized precursor proteins...
9.
Ahting U, Thieffry M, Engelhardt H, Hegerl R, Neupert W, Nussberger S
J Cell Biol
. 2001 Jun;
153(6):1151-60.
PMID: 11402060
Tom40 is the main component of the preprotein translocase of the outer membrane of mitochondria (TOM complex). We have isolated Tom40 of Neurospora crassa by removing the receptor Tom22 and...
10.
Westermann B, Herrmann J, Neupert W
Methods Cell Biol
. 2001 May;
65:429-38.
PMID: 11381608
No abstract available.