D M Bickett
Overview
Explore the profile of D M Bickett including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
649
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rabinowitz M, Andrews R, Becherer J, Bickett D, Bubacz D, Conway J, et al.
J Med Chem
. 2001 Nov;
44(24):4252-67.
PMID: 11708926
A program to improve upon the in vitro, in vivo, and physicochemical properties of N-hydroxyformamide TACE inhibitor GW 3333 (1) is described. Using the primary structure of pro-TNF-alpha, along with...
2.
Musso D, ANDERSEN M, Andrews R, Austin R, Beaudet E, Becherer J, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(16):2147-51.
PMID: 11514157
N-Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and TNF-alpha converting enzyme (TACE). Compound 13c possesses good oral and intravenous pharmacokinetics in the...
3.
Conway J, Andrews R, Beaudet B, Bickett D, Boncek V, Brodie T, et al.
J Pharmacol Exp Ther
. 2001 Aug;
298(3):900-8.
PMID: 11504783
Tumor necrosis factor-alpha (TNF)-converting enzyme (TACE) cleaves the precursor form of TNF, allowing the mature form to be secreted into the extracellular space. GW3333, a dual inhibitor of TACE and...
4.
Deng S, Bickett D, Mitchell J, Lambert M, Blackburn R, Carter 3rd H, et al.
J Biol Chem
. 2000 Jul;
275(40):31422-7.
PMID: 10906330
The substrate specificity of human collagenase 3 (MMP-13), a member of the matrix metalloproteinase family, is investigated using a phage-displayed random hexapeptide library containing 2 x 10(8) independent recombinants. A...
5.
Moss M, Jin S, Milla M, Bickett D, Burkhart W, Carter H, et al.
Nature
. 1997 Feb;
385(6618):733-6.
PMID: 9034191
Tumour-necrosis factor-alpha (TNF-alpha) is a cytokine that contributes to a variety of inflammatory disease states. The protein exists as a membrane-bound precursor of relative molecular mass 26K which can be...
6.
Moss M, Jin S, Becherer J, Bickett D, Burkhart W, Chen W, et al.
J Neuroimmunol
. 1997 Feb;
72(2):127-9.
PMID: 9042103
Tumor necrosis factor-alpha is a potent cytokine, secreted primarily by activated monocytes and macrophages, that possesses a broad range of immunomodulating properties. Involvement of this cytokine has been validated in...
7.
Conway J, Trexler S, Wakefield J, Marron B, Emerson D, Bickett D, et al.
Clin Exp Metastasis
. 1996 Mar;
14(2):115-24.
PMID: 8605725
Four potent, synthetic inhibitors of matrix metalloproteinases (MMPs) were assessed as inhibitors of tumor growth and spontaneous metastasis to the lung. Mat Ly Lu rat prostate tumor, LOX human melanoma...
8.
McGeehan G, Bickett D, Wiseman J, Green M, Berman J
Methods Enzymol
. 1995 Jan;
248:35-46.
PMID: 7674932
No abstract available.
9.
McGeehan G, Bickett D, Green M, Kassel D, Wiseman J, Berman J
J Biol Chem
. 1994 Dec;
269(52):32814-20.
PMID: 7806505
The peptide substrate specificities of two matrix metalloproteinases (MMPs), interstitial collagenase (MMP-1), and 92-kDa gelatinase (MMP-9), have been examined. Starting with the parent substrate, Dnp-Pro-Leu-Gly approximately Leu-Trp-Ala-D-Arg-NH2, four separate substrate...
10.
Bickett D, Green M, Wagner C, Roth J, Berman J, McGeehan G
Ann N Y Acad Sci
. 1994 Sep;
732:351-5.
PMID: 7978805
Stromelysin, a member of the matrix metalloproteinase family of enzymes, has been implicated in the pathogenesis of tumor metastasis and inflammatory diseases such as rheumatoid arthritis. To screen prospective inhibitors...