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D L Beeler

Explore the profile of D L Beeler including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 622
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Recent Articles
1.
Beeler D, Aird W, Grant M
J Thromb Haemost . 2018 May; 16(7):1454-1456. PMID: 29734527
No abstract available.
2.
Beeler D, Aird W, Grant M
J Thromb Haemost . 2018 Feb; 16(4):734-748. PMID: 29418058
Summary: Background Previous studies have provided insight into the molecular basis of human tissue factor (TF) activation of activated factor VII (FVIIa). TF-induced allosteric networks of FVIIa activation have been...
3.
Zhang L, Beeler D, Lawrence R, Lech M, Liu J, Davis J, et al.
J Biol Chem . 2001 Sep; 276(45):42311-21. PMID: 11551899
Using recombinant retroviral transduction, we have introduced the heparin/heparan sulfate (HS) 3-O-sulfotransferase 1 (3-OST-1) gene into Chinese hamster ovary (CHO) cells. Expression of 3-OST-1 confers upon CHO cells the ability...
4.
Enjyoji K, Sevigny J, Lin Y, Frenette P, Christie P, Esch 2nd J, et al.
Nat Med . 1999 Sep; 5(9):1010-7. PMID: 10470077
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged bleeding times with minimally perturbed coagulation parameters. Platelet interactions with...
5.
Christie P, Beeler D, Healy A, Hancock W, Rayburn H, Edelberg J, et al.
J Clin Invest . 1998 Jun; 101(9):1983-91. PMID: 9576763
The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C and suppression...
6.
Kuter D, Beeler D, Rosenberg R
Proc Natl Acad Sci U S A . 1994 Nov; 91(23):11104-8. PMID: 7972018
The circulating blood platelet is produced by the bone marrow megakaryocyte. In response to a decrease in the platelet count, megakaryocytes increase in number and ploidy. Although this feedback loop...
7.
Ravid K, Kuter D, Beeler D, Doi T, Rosenberg R
Blood . 1993 Jun; 81(11):2885-90. PMID: 8499627
A platelet factor 4 (PF4)-expressing cell line, HELNeo, was derived from the human erythroleukemia cell line, HEL. This was achieved by stable transfection of HEL cells with a construct containing...
8.
Yu K, Morioka H, Fritze L, Beeler D, Jackman R, Rosenberg R
J Biol Chem . 1992 Nov; 267(32):23237-47. PMID: 1331078
The transcriptional start sites of the endogenous human thrombomodulin (TM) gene and transiently expressed TM promoter/CAT gene constructs were defined by nuclease S1 mapping which showed two closely spaced sites...
9.
Ravid K, Doi T, Beeler D, Kuter D, Rosenberg R
Mol Cell Biol . 1991 Dec; 11(12):6116-27. PMID: 1944279
We used various segments of the 5' upstream region of the rat platelet factor 4 (PF4) gene coupled to the human growth hormone gene and heterologous promoters to identify domains...
10.
Ravid K, Beeler D, Rabin M, Ruley H, Rosenberg R
Proc Natl Acad Sci U S A . 1991 Feb; 88(4):1521-5. PMID: 1899930
We have used the 1.1 kilobases of the 5' upstream region of the platelet factor four (PF4) gene coupled to the prokaryotic beta-galactosidase gene to generate two lines of transgenic...