D J Stuehr
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Explore the profile of D J Stuehr including associated specialties, affiliations and a list of published articles.
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118
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6092
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Recent Articles
1.
Erzurum S, Ghosh S, Janocha A, Xu W, Bauer S, Bryan N, et al.
Proc Natl Acad Sci U S A
. 2007 Nov;
104(45):17593-8.
PMID: 17971439
The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as indicated by basal and maximal oxygen consumption...
2.
Koeck T, Stuehr D, Aulak K
Biochem Soc Trans
. 2005 Oct;
33(Pt 6):1399-403.
PMID: 16246129
The conditions of the cellular microenvironment in complex multicellular organisms fluctuate, enforcing permanent adaptation of cells at multiple regulatory levels. Covalent post-translational modifications of proteins provide the short-term response tools...
3.
Ask K, Dijols S, Giroud C, Casse L, Frapart Y, Sari M, et al.
Chem Res Toxicol
. 2003 Dec;
16(12):1547-54.
PMID: 14680368
Nitric oxide synthases (NOSs) are flavohemeproteins that catalyze the oxidation of l-arginine to l-citrulline with formation of the widespread signal molecule NO. Beside their fundamental role in NO biosynthesis, these...
4.
Santolini J, Meade A, Stuehr D
J Biol Chem
. 2001 Oct;
276(52):48887-98.
PMID: 11684690
We previously reported the existence of a special auto-regulation property of neuronal nitric-oxide synthase (NOS) based on NO near-geminate combination and partial trapping of neuronal NOS (nNOS) through a futile...
5.
Aoyagi M, Arvai A, Ghosh S, Stuehr D, Tainer J, Getzoff E
Biochemistry
. 2001 Oct;
40(43):12826-32.
PMID: 11669619
To better understand potential roles of conserved Trp457 of the murine inducible nitric oxide synthase oxygenase domain (iNOS(ox); residues 1-498) in maintaining the structural integrity of the (6R)-5,6,7,8-tetrahydrobiopterin (H(4)B) binding...
6.
Wang Z, Wei C, Ghosh S, Meade A, Hemann C, Hille R, et al.
Biochemistry
. 2001 Oct;
40(43):12819-25.
PMID: 11669618
In nitric oxide synthase (NOS), (6R)-tetrahydrobiopterin (H(4)B) binds near the heme and can reduce a heme-dioxygen intermediate (Fe(II)O(2)) during Arg hydroxylation [Wei, C.-C., Wang, Z.-Q., Wang, Q., Meade, A. L.,...
7.
Aulak K, Miyagi M, Yan L, West K, Massillon D, Crabb J, et al.
Proc Natl Acad Sci U S A
. 2001 Oct;
98(21):12056-61.
PMID: 11593016
Inflammation in asthma, sepsis, transplant rejection, and many neurodegenerative diseases associates an up-regulation of NO synthesis with increased protein nitration at tyrosine. Nitration can cause protein dysfunction and is implicated...
8.
Dijols S, Perollier C, Pethe S, Attias R, Boucher J, Stuehr D, et al.
J Med Chem
. 2001 Sep;
44(20):3199-202.
PMID: 11563918
No abstract available.
9.
Couture M, Adak S, Stuehr D, Rousseau D
J Biol Chem
. 2001 Aug;
276(41):38280-8.
PMID: 11479310
Nitric-oxide synthase (NOS) catalyzes the formation of NO and citrulline from l-arginine and oxygen. However, the NO so formed has been found to auto-inhibit the enzymatic activity significantly. We hypothesized...
10.
Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran P, Aulak K, et al.
Arch Biochem Biophys
. 2001 Jun;
390(2):287-94.
PMID: 11396931
Nitric oxide (NO) can modulate numerous genes through several pathways, yet some genes may be modulated only in the presence of the inflammatory stimuli that upregulate the inducible nitric oxide...