D J Lenschow
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Explore the profile of D J Lenschow including associated specialties, affiliations and a list of published articles.
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17
Citations
2895
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Recent Articles
1.
Salomon B, Lenschow D, Rhee L, Ashourian N, Singh B, Sharpe A, et al.
Immunity
. 2000 May;
12(4):431-40.
PMID: 10795741
CD28/B7 costimulation has been implicated in the induction and progression of autoimmune diseases. Experimentally induced models of autoimmunity have been shown to be prevented or reduced in intensity in mice...
2.
Vanderlugt C, Karandikar N, Lenschow D, Dal Canto M, Bluestone J, Miller S
J Neuroimmunol
. 1997 Dec;
79(2):113-8.
PMID: 9394783
PLP139-151-induced experimental autoimmune encephalomyelitis in the SJL mouse is a Th1-mediated inflammatory demyelinating disease characterized by a relapsing-remitting clinical course (R-EAE). Clinical relapses are mediated by T cells specific for...
3.
Herold K, Lenschow D, Bluestone J
Immunol Res
. 1997 Feb;
16(1):71-84.
PMID: 9048209
The initiation and progression of autoimmune diseases, such as insulin-dependent diabetes mellitus (IDDM), are complex processes that depend on autoantigen exposure, genetic susceptibility, and secondary events that promote autoaggression. T-cell...
4.
Lenschow D, Herold K, Rhee L, Patel B, KOONS A, Qin H, et al.
Immunity
. 1996 Sep;
5(3):285-93.
PMID: 8808683
CD28 ligation delivers a costimulatory signal important in T cell activation. This study demonstrates that the disruption of the CD28/B7 pathway early in the nonobese diabetic mouse strain, using CD28-/-...
5.
Lenschow D, Walunas T, Bluestone J
Annu Rev Immunol
. 1996 Jan;
14:233-58.
PMID: 8717514
T cells play a central role in the initiation and regulation of the immune response to antigen. Both the engagement of the TCR with MHC/Ag and a second signal are...
6.
Miller S, Vanderlugt C, Lenschow D, Pope J, Karandikar N, Dal Canto M, et al.
Immunity
. 1995 Dec;
3(6):739-45.
PMID: 8777719
Relapsing experimental autoimmune encephalomyelitis (R-EAE) induced with the immunodominant epitope from proteolipid protein, PLP139-151, is characterized by the development of recurrent relapses with recruitment of T cells reactive to additional...
7.
Lenschow D, Zeng Y, Hathcock K, Zuckerman L, Freeman G, Thistlethwaite J, et al.
Transplantation
. 1995 Nov;
60(10):1171-8.
PMID: 7482727
Antigen-specific T cell activation depends initially on the interaction of the T cell receptor (TCR) with peptide/MHC. In addition, a costimulatory signal, mediated by distinct cell surface accessory molecules, is...
8.
Green J, Noel P, Sperling A, Walunas T, Lenschow D, Stack R, et al.
Proc Assoc Am Physicians
. 1995 Apr;
107(1):41-6.
PMID: 8630743
No abstract available.
9.
Lenschow D, Ho S, Sattar H, Rhee L, Gray G, Nabavi N, et al.
J Exp Med
. 1995 Mar;
181(3):1145-55.
PMID: 7532678
Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete destruction of the insulin-producing islets of Langerhans. It has become increasingly clear that autoreactive...
10.
Alegre M, Lenschow D, Bluestone J
Dig Dis Sci
. 1995 Jan;
40(1):58-64.
PMID: 7821120
The main objective of our studies has been to optimize the effects of monoclonal antibodies (MAbs) and other immunosuppressive reagents to enhance organ graft survival. One such agent is OKT3,...