D H Randle
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Explore the profile of D H Randle including associated specialties, affiliations and a list of published articles.
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5
Citations
849
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Recent Articles
1.
Inoue K, Zindy F, Randle D, Rehg J, Sherr C
Genes Dev
. 2001 Nov;
15(22):2934-9.
PMID: 11711428
Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age. Retention and expression of the...
2.
Randle D, Zindy F, Sherr C, Roussel M
Proc Natl Acad Sci U S A
. 2001 Aug;
98(17):9654-9.
PMID: 11481442
Establishment of cell lines from primary mouse embryo fibroblasts depends on loss of either the Arf tumor suppressor or its downstream target, the p53 transcription factor. Mouse p19(Arf) is encoded...
3.
Weber J, Jeffers J, Rehg J, Randle D, Lozano G, Roussel M, et al.
Genes Dev
. 2000 Sep;
14(18):2358-65.
PMID: 10995391
The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency...
4.
Kamijo T, Bodner S, Van de Kamp E, Randle D, Sherr C
Cancer Res
. 1999 May;
59(9):2217-22.
PMID: 10232611
The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2. Mice lacking ARF are...
5.
Zindy F, Eischen C, Randle D, Kamijo T, Cleveland J, Sherr C, et al.
Genes Dev
. 1998 Aug;
12(15):2424-33.
PMID: 9694806
Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical...