D G Hirst
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Explore the profile of D G Hirst including associated specialties, affiliations and a list of published articles.
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96
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1067
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Recent Articles
1.
Jain S, Hirst D, OSullivan J
Br J Radiol
. 2011 Oct;
85(1010):101-13.
PMID: 22010024
Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology...
2.
Hirst D, Robson T
Br J Radiol
. 2010 Aug;
83(993):723-8.
PMID: 20739343
We know considerably more about what makes cells and tissues resistant or sensitive to radiation than we did 20 years ago. Novel techniques in molecular biology have made a major...
3.
Butterworth K, Coulter J, Jain S, Forker J, McMahon S, Schettino G, et al.
Nanotechnology
. 2010 Jul;
21(29):295101.
PMID: 20601762
High atomic number (Z) materials such as gold preferentially absorb kilovoltage x-rays compared to soft tissue and may be used to achieve local dose enhancement in tumours during treatment with...
4.
Wyer J, Butterworth K, Hirst D, Latimer C, Montenegro E, Shah M, et al.
Phys Med Biol
. 2009 Jul;
54(15):4705-21.
PMID: 19590119
The results of an investigation into the damage caused to dry plasmid DNA after irradiation by fast (keV) hydrogen atoms are presented. Agarose gel electrophoresis was used to assess single...
5.
Butterworth K, Wyer J, Brennan-Fournet M, Latimer C, Shah M, Currell F, et al.
Radiat Res
. 2008 Sep;
170(3):381-7.
PMID: 18763863
Using agarose gel electrophoresis, we measured the effectiveness of high-Z metal particles of different sizes on SSB and DSB yields for plasmid DNA irradiated with 160 kVp X rays. For...
6.
Marignol L, Robson T, McCarthy H, Worthington J, Murray M, Hollywood D, et al.
J Gene Med
. 2008 Jul;
10(9):1032-8.
PMID: 18615772
Background: Radiation therapy is a treatment modality routinely used in cancer management so it is not unexpected that radiation-inducible promoters have emerged as an attractive tool for controlled gene therapy....
7.
Coulter J, McCarthy H, Xiang J, Roedl W, Wagner E, Robson T, et al.
Nitric Oxide
. 2008 May;
19(2):192-8.
PMID: 18485922
Much research over the past two decades has focussed on understanding the complex interactions of nitric oxide (NO(.)) in both physiological and pathological processes. As with many other aspects of...
8.
Coulter J, McCarthy H, Worthington J, Robson T, Scott S, Hirst D
Gene Ther
. 2008 Feb;
15(7):495-503.
PMID: 18256696
Driving high-level transgene expression in a tumour-specific manner remains a key requirement in the development of cancer gene therapy. We have previously demonstrated the strong anticancer effects of generating abnormally...
9.
10.
McCarthy H, Worthington J, Barrett E, Cosimo E, Boyd M, Mairs R, et al.
Gene Ther
. 2006 Sep;
14(3):246-55.
PMID: 17006546
Cancer gene therapy that utilizes toxic transgene products requires strict transcriptional targeting to prevent adverse normal tissue effects. We report on the use of a promoter derived from the cyclin...