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D F Coakley

Explore the profile of D F Coakley including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 171
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Recent Articles
1.
Mokhtarani M, Diaz G, Lichter-Konecki U, Berry S, Bartley J, McCandless S, et al.
Mol Genet Metab Rep . 2017 Jun; 5:12-14. PMID: 28649536
Urinary phenylacetylglutamine (U-PAGN) concentrations in spot urine samples were analyzed as a dosing biomarker during glycerol phenylbutyrate (GPB) dosing in 68 healthy adults and 66 adult and pediatric patients with...
2.
Bajaj J, Frederick R, Bass N, Ghabril M, Coyne K, Margolis M, et al.
Metab Brain Dis . 2016 Jun; 31(5):1081-93. PMID: 27278222
Clinical management and clinical trials of patients with overt hepatic encephalopathy (OHE) are compromised by lack of standardized and reproducible tools for its clinical diagnosis or for caregiver (CG) identification...
3.
Landis C, Ghabril M, Rustgi V, Di Bisceglie A, Maliakkal B, Rockey D, et al.
Dig Dis Sci . 2016 Jan; 61(6):1728-34. PMID: 26781427
Background: Overt hepatic encephalopathy (OHE) is a frequent complication of decompensated cirrhosis. Aims: A multicenter prospective observational study was performed to assess the most commonly recorded presenting manifestations of OHE...
4.
Lee B, Diaz G, Rhead W, Lichter-Konecki U, Feigenbaum A, Berry S, et al.
Mol Genet Metab . 2015 Nov; 117(1):27-32. PMID: 26586473
Unlabelled: Blood ammonia and glutamine levels are used as biomarkers of control in patients with urea cycle disorders (UCDs). This study was undertaken to evaluate glutamine variability and utility as...
5.
Mokhtarani M, Diaz G, Rhead W, Lichter-Konecki U, Bartley J, Feigenbaum A, et al.
Mol Genet Metab . 2012 Sep; 107(3):308-14. PMID: 22958974
Unlabelled: We have analyzed pharmacokinetic data for glycerol phenylbutyrate (also GT4P or HPN-100) and sodium phenylbutyrate with respect to possible dosing biomarkers in patients with urea cycle disorders (UCD). Study...
6.
Deeks S, Barditch-Crovo P, Collier A, Smith A, Miller M, McGowan I, et al.
J Acquir Immune Defic Syndr . 2001 Nov; 28(4):336-9. PMID: 11707669
Tenofovir disoproxil fumarate (DF) is an adenosine analogue with significant activity against HIV-1. Hydroxyurea decreases the intracellular concentrations of deoxyadenosine triphosphate, the active metabolite of adenosine. We therefore tested the...
7.
Barditch-Crovo P, Deeks S, Collier A, Safrin S, Coakley D, Miller M, et al.
Antimicrob Agents Chemother . 2001 Sep; 45(10):2733-9. PMID: 11557462
Tenofovir DF is an antiviral nucleotide with activity against human immunodeficiency virus type 1 (HIV-1). The pharmacokinetics, safety, and activity of oral tenofovir DF in HIV-1-infected adults were evaluated in...
8.
Hughes W, Shenep J, Rodman J, Fridland A, Willoughby R, Blanchard S, et al.
Antimicrob Agents Chemother . 2000 Mar; 44(4):1041-6. PMID: 10722509
The acyclic phosphonate analog adefovir is a potent inhibitor of retroviruses, including human immunodeficiency virus (HIV) type 1, and, unlike some antiviral nucleosides, does not require the initial phosphorylation step...
9.
Knupp C, Hak L, Coakley D, Falk R, Wagner B, Raasch R, et al.
Clin Pharmacol Ther . 1996 Nov; 60(5):535-42. PMID: 8941026
Objective: To evaluate the pharmacokinetics of didanosine in patients with normal kidney function or chronic kidney failure. Methods: Three groups of patients with human immunodeficiency virus (HIV) infection were studied:...