D D Sternbach
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Explore the profile of D D Sternbach including associated specialties, affiliations and a list of published articles.
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15
Citations
1061
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Recent Articles
1.
Liu K, Lambert M, Ayscue A, Henke B, Leesnitzer L, Oliver Jr W, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(24):3111-3.
PMID: 11720854
A series of PPARgamma agonists were synthesized from L-tyrosine that incorporated low molecular weight N-substituents. The most potent analogue, pyrrole (4e), demonstrated a K(i) of 6.9nM and an EC(50) of...
2.
Liu K, Lambert M, Leesnitzer L, Oliver Jr W, Ott R, Plunket K, et al.
Bioorg Med Chem Lett
. 2001 Oct;
11(22):2959-62.
PMID: 11677135
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound...
3.
Liu K, Smith J, Ayscue A, Henke B, Lambert M, Leesnitzer L, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(17):2385-8.
PMID: 11527737
A series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with dual agonist activity on PPARalpha and PPARgamma is described. Several of these compounds also showed partial agonist activity on PPARdelta. Resolution of...
4.
Oliver Jr W, Shenk J, Snaith M, Russell C, Plunket K, Bodkin N, et al.
Proc Natl Acad Sci U S A
. 2001 Apr;
98(9):5306-11.
PMID: 11309497
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs and the antidiabetic effects of the glitazone...
5.
Willson T, Brown P, Sternbach D, Henke B
J Med Chem
. 2000 Feb;
43(4):527-50.
PMID: 10691680
No abstract available.
6.
Xu H, Lambert M, Montana V, Parks D, Blanchard S, Brown P, et al.
Mol Cell
. 1999 Apr;
3(3):397-403.
PMID: 10198642
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the crystal structure of the PPAR delta ligand-binding domain (LBD)...
7.
Alligood K, Charifson P, Crosby R, Consler T, Feldman P, Gampe Jr R, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(10):1189-94.
PMID: 9871733
The X-ray crystal structure of the src SH2 domain revealed the presence of a thiol residue (Cys 188) located proximal to the phosphotyrosine portion of a dipeptide ligand. An aldehyde...
8.
Pacofsky G, Lackey K, Alligood K, Berman J, Charifson P, Crosby R, et al.
J Med Chem
. 1998 Jun;
41(11):1894-908.
PMID: 9599239
The design, synthesis, and evaluation of dipeptide analogues as ligands for the pp60c-src SH2 domain are described. The critical binding interactions between Ac-Tyr-Glu-N(n-C5H11)2 (2) and the protein are established and...
9.
Brown P, Charifson P, Tomkinson N, Fivush A, Sternbach D, Wade L, et al.
Chem Biol
. 1998 Mar;
4(12):909-18.
PMID: 9427656
Background: The peroxisome proliferator-activated receptors (PPARs) were cloned as orphan members of the nuclear receptor superfamily of transcription factors. The identification of subtype-selective ligands for PPARalpha and PPARgamma has led...
10.
Charifson P, Shewchuk L, Rocque W, Hummel C, Jordan S, Mohr C, et al.
Biochemistry
. 1997 May;
36(21):6283-93.
PMID: 9174343
Thermodynamic measurements, structural determinations, and molecular computations were applied to a series of peptide ligands of the pp60(c-src) SH2 domain in an attempt to understand the critical binding determinants for...