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D Clive Williams

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Articles 68
Citations 499
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Recent Articles
1.
McKeown J, Byrne A, Bright S, Charleton C, Kandwal S, cmelo I, et al.
Pharmaceuticals (Basel) . 2024 Aug; 17(8). PMID: 39204139
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells, and it is the most frequent form of leukemia diagnosed in Western countries. It is characterized by the proliferation...
2.
Bright S, Erby M, Poynton F, Monteyne D, Perez-Morga D, Gunnlaugsson T, et al.
RSC Chem Biol . 2024 Apr; 5(4):344-359. PMID: 38576718
Ruthenium(ii) complexes are attracting significant research attention as a promising class of photosensitizers (PSs) in photodynamic therapy (PDT). Having previously reported the synthesis of two novel Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base compounds...
3.
Byrne A, Bright S, McKeown J, Bergin A, Twamley B, McElligott A, et al.
Molecules . 2023 Dec; 28(24). PMID: 38138584
Chronic lymphocytic leukaemia (CLL) is a malignancy of the immune B lymphocyte cells and is the most common leukaemia diagnosed in developed countries. In this paper, we report the synthesis...
4.
Keane P, Zehe C, Poynton F, Bright S, Estayalo-Adrian S, Devereux S, et al.
Phys Chem Chem Phys . 2023 Aug; 25(34):23316-23317. PMID: 37594131
Correction for 'Time-resolved infra-red studies of photo-excited porphyrins in the presence of nucleic acids and in HeLa tumour cells: insights into binding site and electron transfer dynamics' by Páraic M....
5.
Keane P, Zehe C, Poynton F, Bright S, Estayalo-Adrian S, Devereux S, et al.
Phys Chem Chem Phys . 2022 Nov; 24(44):27524-27531. PMID: 36345709
Cationic porphyrins based on the 5,10,15,20--(tetrakis-4--methylpyridyl) core (TMPyP4) have been studied extensively over many years due to their strong interactions with a variety of nucleic acid structures, and their potential...
6.
Estalayo-Adrian S, Blasco S, Bright S, McManus G, Orellana G, Williams D, et al.
ACS Appl Bio Mater . 2022 Jan; 4(9):6664-6681. PMID: 35006970
A family of six Ru(II) polypyridyl complexes (-) which contain phenanthroline-based ligands functionalized with alkyl chains of different lengths (one methyl group, 10 and 21 carbon alkyl chains) and either...
7.
Calatrava-Perez E, Marchetti L, McManus G, Lynch D, Elmes R, Williams D, et al.
Chemistry . 2021 Nov; 28(3):e202103858. PMID: 34820925
Real-time tracking of prodrug uptake, delivery and activation in vivo represents a major challenge for prodrug development. Herein, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore...
8.
Elmes R, Ryan G, Erby M, Frimannsson D, Kitchen J, Lawler M, et al.
Inorg Chem . 2020 Jul; 59(15):10874-10893. PMID: 32672449
We report the synthesis, photophysical characterization, and biological evaluation of four DNA-binding ruthenium(II) polypyridyl 4-nitro- and 4-amino-1,8-naphthalimide conjugates. A meta arrangement around the ring connecting the 1,8-naphthalimide to a bipyridine...
9.
Estalayo-Adrian S, Blasco S, Bright S, McManus G, Orellana G, Williams D, et al.
Chem Commun (Camb) . 2020 Jul; 56(65):9332-9335. PMID: 32671364
Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid...
10.
Byrne A, Bright S, McKeown J, OBrien J, Twamley B, Fayne D, et al.
Pharmaceuticals (Basel) . 2020 Jan; 13(1). PMID: 31963567
Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt's lymphoma (BL) is a rare form of non-Hodgkin's lymphoma in which the cancer starts in the...