Water-soluble Amphiphilic Ruthenium(ii) Polypyridyl Complexes As Potential Light-activated Therapeutic Agents

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2020 Jul 17

PMID 32671364

Citations 2

Authors

Sandra Estalayo-Adrian

Salvador Blasco

Sandra A Bright

Gavin J McManus

Guillermo Orellana

D Clive Williams

John M Kelly

Thorfinnur Gunnlaugsson

Affiliations

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Abstract

Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.

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