D Altshuler
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Explore the profile of D Altshuler including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
3346
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Recent Articles
11.
Sachidanandam R, Weissman D, Schmidt S, Kakol J, Stein L, Marth G, et al.
Nature
. 2001 Mar;
409(6822):928-33.
PMID: 11237013
We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed throughout the human genome, providing an average density on available sequence of one SNP every 1.9 kilobases. These...
12.
Moore K, Rosen E, Fitzgerald M, RANDOW F, Andersson L, Altshuler D, et al.
Nat Med
. 2001 Jan;
7(1):41-7.
PMID: 11135614
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, is reported to mediate macrophage differentiation and inflammatory responses. Using PPAR-gamma-deficient stem cells, we demonstrate that...
13.
Altshuler D, Pollara V, Cowles C, Van Etten W, Baldwin J, Linton L, et al.
Nature
. 2000 Oct;
407(6803):513-6.
PMID: 11029002
Most genomic variation is attributable to single nucleotide polymorphisms (SNPs), which therefore offer the highest resolution for tracking disease genes and population history. It has been proposed that a dense...
14.
Altshuler D, Daly M, Kruglyak L
Nat Genet
. 2000 Oct;
26(2):135-7.
PMID: 11017062
No abstract available.
15.
Altshuler D, Hirschhorn J, Klannemark M, Lindgren C, Vohl M, Nemesh J, et al.
Nat Genet
. 2000 Sep;
26(1):76-80.
PMID: 10973253
Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in multiple samples and with...
16.
Sidow A, Bulotsky M, Kerrebrock A, Birren B, Altshuler D, Jaenisch R, et al.
Nat Genet
. 1999 Sep;
23(1):104-7.
PMID: 10471509
Early outgrowth of the vertebrate embryonic limb requires signalling by the apical ectodermal ridge (AER) to the progress zone (PZ), which in response proliferates and lays down the pattern of...
17.
18.
Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, et al.
Nat Genet
. 1999 Jul;
22(3):231-8.
PMID: 10391209
A major goal in human genetics is to understand the role of common genetic variants in susceptibility to common diseases. This will require characterizing the nature of gene variation in...
19.
Ross R, Coetzee G, Pearce C, Reichardt J, Bretsky P, Kolonel L, et al.
Eur Urol
. 1999 May;
35(5-6):355-61.
PMID: 10325489
The prostate is an androgen-regulated organ, which has led to longstanding interest in the role of androgens in prostate carcinogenesis. Although evidence of a hormonal etiology for prostate cancer is...
20.
Altshuler D, Kruglyak L, LANDER E
N Engl J Med
. 1998 May;
338(22):1626.
PMID: 9606122
No abstract available.