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D Gaudet

Explore the profile of D Gaudet including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 58
Citations 1922
Followers 0
Related Specialties
Genetics
Endocrinology
Cardiology & Vascular Diseases
Top 10 Co-Authors
M C Vohl
J P Despres
C Gagne
P Perron
D Brisson
J Bergeron
P Hamet
G Tremblay
Z Pausova
S Moorjani
Published In
Hypertension
Atherosclerosis
Mol Genet Metab
Clin Genet
Am J Hum Genet
Affiliations
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Recent Articles
1.
Visceral fat enhances blood pressure reactivity to physical but not mental challenges in male adolescents
Van Woudenberg M, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, et al.
Pediatr Obes . 2015 Sep; 10(5):395-402. PMID: 26364941
Background: Excess visceral fat is a major risk factor for hypertension. Enhanced blood pressure (BP) reactivity and delayed BP recovery from physical and mental challenges predict future hypertension. Objectives: Determine...
2.
The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia - a post-hoc analysis of a Phase 3, single-arm, open-label trial
Stefanutti C, Blom D, Averna M, Meagher E, Theron H, Marais A, et al.
Atherosclerosis . 2015 Apr; 240(2):408-14. PMID: 25897792
Objective: Lomitapide (a microsomal triglyceride transfer protein inhibitor) is an adjunctive treatment for homozygous familial hypercholesterolaemia (HoFH), a rare genetic condition characterised by elevated low-density lipoprotein-cholesterol (LDL-C), and premature, severe,...
3.
Saguenay Youth Study: a multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health
Paus T, Pausova Z, Abrahamowicz M, Gaudet D, Leonard G, Pike G, et al.
Dev Cogn Neurosci . 2014 Dec; 11:129-44. PMID: 25454417
This paper provides an overview of the Saguenay Youth Study (SYS) and its parental arm. The overarching goal of this effort is to develop trans-generational models of developmental cascades contributing...
4.
Placental lipoprotein lipase DNA methylation levels are associated with gestational diabetes mellitus and maternal and cord blood lipid profiles
Houde A, St-Pierre J, Hivert M, Baillargeon J, Perron P, Gaudet D, et al.
J Dev Orig Health Dis . 2014 May; 5(2):132-41. PMID: 24847699
Placental lipoprotein lipase (LPL) is crucial for placental lipid transfer. Impaired LPL gene expression and activity were reported in pregnancies complicated by gestational diabetes mellitus (GDM) and intra-uterine growth restriction....
5.
DNA methylation variations at CETP and LPL gene promoter loci: new molecular biomarkers associated with blood lipid profile variability
Guay S, Brisson D, Lamarche B, Marceau P, Vohl M, Gaudet D, et al.
Atherosclerosis . 2013 Apr; 228(2):413-20. PMID: 23623643
Background: Recent findings suggest that DNA methylation, a well-known epigenetic mechanism, is involved in high-density lipoprotein cholesterol (HDL-C) metabolism and increased cardiovascular disease risk. The aim of this study was...
6.
Opioid receptor mu 1 gene, fat intake and obesity in adolescence
Haghighi A, Melka M, Bernard M, Abrahamowicz M, Leonard G, Richer L, et al.
Mol Psychiatry . 2013 Jan; 19(1):63-8. PMID: 23337944
Dietary preference for fat may increase risk for obesity. It is a complex behavior regulated in part by the amygdala, a brain structure involved in reward processing and food behavior,...
7.
Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population
Arenas I, Tremblay J, Deslauriers B, Sandoval J, Seda O, Gaudet D, et al.
Physiol Genomics . 2012 Dec; 45(4):138-50. PMID: 23269701
Blood pressure (BP) is a dynamic phenotype that varies rapidly to adjust to changing environmental conditions. Standing upright is a recent evolutionary trait, and genetic factors that influence postural adaptations...
8.
Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial
Gaudet D, Methot J, Dery S, Brisson D, Essiembre C, Tremblay G, et al.
Gene Ther . 2012 Jun; 20(4):361-9. PMID: 22717743
We describe the 2-year follow-up of an open-label trial (CT-AMT-011-01) of AAV1-LPL(S447X) gene therapy for lipoprotein lipase (LPL) deficiency (LPLD), an orphan disease associated with chylomicronemia, severe hypertriglyceridemia, metabolic complications...
9.
The g.-469G>A polymorphism in the GPIHBP1 gene promoter is associated with hypertriglyceridemia and has an additive effect on the risk conferred by LPL defective alleles
Guay S, Gaudet D, Brisson D
Nutr Metab Cardiovasc Dis . 2011 Oct; 23(4):358-65. PMID: 21978733
Background And Aims: Hypertriglyceridemia (hyperTG) is a component of the metabolic syndrome and a cardiovascular or pancreatitis risk factor. Although both genetic and environmental factors influence its expression, the biological...
10.
Health supervision and anticipatory guidance in adult myotonic dystrophy type 1
Gagnon C, Chouinard M, Laberge L, Veillette S, Begin P, Breton R, et al.
Neuromuscul Disord . 2010 Oct; 20(12):847-51. PMID: 20884209
The complexity and variability of disease manifestations in myotonic dystrophy (DM1) pose a challenge for the clinical management of patients. The follow-up of DM1 patients has been described as fragmented,...