D A Gamache
Overview
Explore the profile of D A Gamache including associated specialties, affiliations and a list of published articles.
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19
Citations
240
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Recent Articles
1.
Kapin M, Yanni J, Brady M, McDonough T, Flanagan J, Rawji M, et al.
Inflammation
. 2003 Nov;
27(5):281-91.
PMID: 14635785
The purpose of this study was to evaluate the ability of the nonsteroidal anti-inflammatory drug nepafenac to prevent development of mitogen-induced pan-retinal edema following topical ocular application in the rabbit....
2.
Gamache D, Graff G, Brady M, Spellman J, Yanni J
Inflammation
. 2000 Jun;
24(4):357-70.
PMID: 10850857
Nepafenac, the amide analog of 2-amino-3-benzoylbenzeneacetic acid (amfenac), was examined in preclinical models for its potential utility as a topical ocular anti-inflammatory agent. Diclofenac was selected as the reference compound....
3.
Yanni J, Sharif N, Gamache D, Miller S, Weimer L, Spellman J
Acta Ophthalmol Scand Suppl
. 1999 May;
(228):33-7.
PMID: 10337430
Two important realizations about pathophysiological mechanisms involved in allergic conjunctivitis have led to novel drug discovery efforts and new topical ocular medications for prevention and treatment of this prevent allergic...
4.
Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs
Yanni J, Weimer L, Sharif N, Xu S, Gamache D, Spellman J
Arch Ophthalmol
. 1999 May;
117(5):643-7.
PMID: 10326962
Objective: To evaluate the effects of topical ocular drugs with histamine H1-antagonist activity on histamine-stimulated phosphatidylinositol turnover and interleukin (IL) 6 and IL-8 secretion from human conjunctival epithelial cells. Methods:...
5.
Graff G, Brady M, Gamache D, Spellman J, Yanni J
Ocul Immunol Inflamm
. 1999 Jan;
6(4):227-38.
PMID: 9924919
The trauma-induced acute ocular inflammatory response has been characterized by investigating the kinetics of blood-aqueous barrier (BAB) breakdown, prostaglandin (PG) accumulation in the aqueous humor, and cyclooxygenase (PGH synthase) activity...
6.
Graff G, Gamache D, Brady M, Spellman J, Yanni J
J Pharmacol Toxicol Methods
. 1998 Sep;
39(3):169-78.
PMID: 9741392
Previously described models of endotoxin-induced uveitis quantify neutrophil influx into the eye using biochemical or direct cell count methods that result in an underestimation of ocular leukocyte accumulation following the...
7.
Weimer L, Gamache D, Yanni J
Int Arch Allergy Immunol
. 1998 May;
115(4):288-93.
PMID: 9566351
The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner. The histamine antagonists emedastine (H1),...
8.
Yanni J, Miller S, Gamache D, Spellman J, Xu S, Sharif N
Ann Allergy Asthma Immunol
. 1998 Jan;
79(6):541-5.
PMID: 9433371
Background: The concept of mast cell heterogeneity is well established. Recent data indicate that human conjunctival tissue mast cells and human connective tissue mast cells respond to various secretagogues in...
9.
Miller S, Barney N, Gamache D, Spellman J, Yanni J
Int Arch Allergy Immunol
. 1997 Oct;
114(2):139-43.
PMID: 9338607
Background: Mast cells have been identified in the choroid of numerous species including man. However, functional studies involving these human mast cells have not been reported. In the current studies,...
10.
Gamache D, Dimitrijevich S, Weimer L, Lang L, Spellman J, Graff G, et al.
Ocul Immunol Inflamm
. 1997 Jun;
5(2):117-28.
PMID: 9234376
The production of cytokines by human conjunctival epithelial cells following stimulation was investigated. Primary cultures of human conjunctival epithelial cells were characterized by morphology and keratin expression. Cultured epithelial cells...