D A Gamache
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Explore the profile of D A Gamache including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
240
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Recent Articles
11.
Sharif N, Xu S, Miller S, Gamache D, Yanni J
J Pharmacol Exp Ther
. 1996 Sep;
278(3):1252-61.
PMID: 8819509
Olopatadine (AL-4943A; KW-4679) [(Z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2-acetic acid hydrochloride] is an antiallergic/antihistaminic drug under development for topical ocular use. The effects of the compound on release of proinflammatory mediators (histamine, tryptase and...
12.
Yanni J, Stephens D, Miller S, Weimer L, Graff G, Parnell D, et al.
J Ocul Pharmacol Ther
. 1996 Jan;
12(4):389-400.
PMID: 8951675
Olopatadine (AL-4943A; KW-4679) [(z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2 acetic acid hydrochloride] is an anti-allergic agent which inhibits mast cell mediator release and possesses histamine H1 receptor antagonist activity. Studies were conducted to characterize...
13.
Fruman D, Gamache D, Ernest M
Agents Actions
. 1991 Sep;
34(1-2):16-9.
PMID: 1665289
Changes in the endogenous synthesis of inositol 1,4,5-trisphosphate (IP3) mass have been quantitated in human peripheral neutrophils stimulated with FMLP, LTB4 and PAF using a recently described, highly specific radioreceptor...
14.
Gamache D, Fawzy A, Franson R
Biochim Biophys Acta
. 1988 Jan;
958(1):116-24.
PMID: 3334860
The susceptibility of partially peroxidized liposomes of 2-[1-14C] linoleoylphosphatidylethanolamine ([14C]PE) to hydrolysis by cellular phospholipases was examined. [14C]PE was peroxidized by exposure to air at 37 degrees C, resulting in...
15.
Gamache D, Hess M, Franson R
Basic Res Cardiol
. 1987 Jan;
82 Suppl 1:113-9.
PMID: 3663002
Phospholipid alterations and phospholipase activities were studied in a preparation of canine cardiac sarcoplasmic reticulum (SR) known to contain lysosomes. Incubation of SR at pH 5.0 (37 degrees C) resulted...
16.
Gamache D, ELLIS E
J Neurosurg
. 1986 Nov;
65(5):686-92.
PMID: 3772457
A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR). This model is characterized by increased brain water and vascular permeability, by neutrophil...
17.
Gamache D, Povlishock J, ELLIS E
J Neurosurg
. 1986 Nov;
65(5):679-85.
PMID: 3772456
Administration of the mucopolysaccharide, carrageenan (CAR), into the hind paw of the rat or mouse induces a local inflammation characterized by increased arachidonic acid metabolism, increased vascular permeability, edema, and...
18.
Gamache D, Kornberg L, Bartolf M, Franson R
Biochim Biophys Acta
. 1986 Jun;
858(1):217-20.
PMID: 3754767
Using [1-14C]oleate-labelled autoclaved Escherichia coli as substrate, we demonstrate that many, but not all, commercial preparations of xanthine oxidase contain phospholipase A2 activity as a contaminant. Phospholipase A2 activity (64.3-545.6...
19.
Adesuyi S, Cockrell C, Gamache D, ELLIS E
J Neurochem
. 1985 Sep;
45(3):770-6.
PMID: 3928809
When blood-free mouse brain slices were incubated with exogenous radiolabeled arachidonic acid, gas chromatography/mass spectrometry confirmed that the major radioactive lipoxygenase enzyme product of arachidonic acid was 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE),...