Cynthia T McMurray
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Explore the profile of Cynthia T McMurray including associated specialties, affiliations and a list of published articles.
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59
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2615
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Recent Articles
1.
Polyzos A, Cheong A, Yoo J, Blagec L, Toprani S, Nagel Z, et al.
Nat Commun
. 2024 Sep;
15(1):7726.
PMID: 39231940
We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check...
2.
Laverde E, Polyzos A, Tsegay P, Shaver M, Hutcheson J, Balakrishnan L, et al.
Genes (Basel)
. 2023 Jan;
14(1).
PMID: 36672839
Flap endonuclease 1 (FEN1) is an essential enzyme that removes RNA primers and base lesions during DNA lagging strand maturation and long-patch base excision repair (BER). It plays a crucial...
3.
Xun Z, Wipf P, McMurray C
J Huntingtons Dis
. 2022 Apr;
11(2):141-151.
PMID: 35404288
Background: Mitochondria (MT) are energy "powerhouses" of the cell and the decline in their function from oxidative damage is strongly correlated in many diseases. To suppress oxygen damage, we have...
4.
Wipf P, Polyzos A, McMurray C
J Huntingtons Dis
. 2021 Dec;
11(1):3-15.
PMID: 34924397
Due to large increases in the elderly populations across the world, age-related diseases are expected to expand dramatically in the coming years. Among these, neurodegenerative diseases will be among the...
5.
Lovergne L, Ghosh D, Schuck R, Polyzos A, Chen A, Martin M, et al.
Sci Rep
. 2021 Aug;
11(1):15598.
PMID: 34341363
Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms,...
6.
Sammi S, Foguth R, Nieves C, de Perre C, Wipf P, McMurray C, et al.
Toxicol Sci
. 2019 Aug;
172(2):417-434.
PMID: 31428778
Perfluorooctane sulfonate (PFOS) has been widely utilized in numerous industries. Due to long environmental and biological half-lives, PFOS is a major public health concern. Although the literature suggests that PFOS...
7.
Polyzos A, Lee D, Datta R, Hauser M, Budworth H, Holt A, et al.
Cell Metab
. 2019 Apr;
29(6):1258-1273.e11.
PMID: 30930170
The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals,...
8.
Bjerregaard V, Garribba L, McMurray C, Hickson I, Liu Y
Proc Natl Acad Sci U S A
. 2018 Dec;
115(51):13003-13008.
PMID: 30509972
The instability of chromosome fragile sites is implicated as a causative factor in several human diseases, including cancer [for common fragile sites (CFSs)] and neurological disorders [for rare fragile sites...
9.
Polyzos A, Wood N, Williams P, Wipf P, Morton A, McMurray C
PLoS One
. 2018 Apr;
13(4):e0194580.
PMID: 29630611
We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether...
10.
Polyzos A, McMurray C
DNA Repair (Amst)
. 2017 Jul;
56:144-155.
PMID: 28690053
Expansion of simple triplet repeats (TNR) underlies more than 30 severe degenerative diseases. There is a good understanding of the major pathways generating an expansion, and the associated polymerases that...