Cristian Tomasetti
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Explore the profile of Cristian Tomasetti including associated specialties, affiliations and a list of published articles.
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48
Citations
5928
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Recent Articles
1.
Tie J, Wang Y, Lo S, Lahouel K, Cohen J, Wong R, et al.
Nat Med
. 2025 Mar;
PMID: 40055522
Early data from the DYNAMIC study of circulating tumor DNA (ctDNA)-guided adjuvant chemotherapy (ACT) versus standard approach met its primary outcome demonstrating reduced ACT use without compromising 2-year recurrence-free survival...
2.
Brenner T, Kuo A, Sperna Weiland C, Kamal A, Elmunzer B, Luo H, et al.
Gastrointest Endosc
. 2024 Aug;
101(1):129-138.e0.
PMID: 39147103
Background And Aims: A robust model of post-ERCP pancreatitis (PEP) risk is not currently available. We aimed to develop a machine learning-based tool for PEP risk prediction to aid in...
3.
Douville C, Lahouel K, Kuo A, Grant H, Avigdor B, Curtis S, et al.
Sci Transl Med
. 2024 Jan;
16(731):eadi3883.
PMID: 38266106
We previously described an approach called RealSeqS to evaluate aneuploidy in plasma cell-free DNA through the amplification of ~350,000 repeated elements with a single primer. We hypothesized that an unbiased...
4.
Kimura H, Lahouel K, Tomasetti C, Roberts N
bioRxiv
. 2024 Jan;
PMID: 38234851
Interpretation of variants identified during genetic testing is a significant clinical challenge. In this study, we developed a high-throughput CDKN2A functional assay and characterized all possible missense variants. We found...
5.
Mattox A, Douville C, Wang Y, Popoli M, Ptak J, Silliman N, et al.
Cancer Discov
. 2023 Aug;
13(10):2166-2179.
PMID: 37565753
Significance: The origin of excess cfDNA in patients with cancer is unknown. Using cfDNA methylation patterns, we determined that neither the tumor nor the surrounding normal tissue contributes this excess...
6.
Rahmanuddin S, Jamil A, Chaudhry A, Seto T, Brase J, Motarjem P, et al.
Cancers (Basel)
. 2023 Feb;
15(3).
PMID: 36765610
Background: Cancer patients infected with COVID-19 were shown in a multitude of studies to have poor outcomes on the basis of older age and weak immune systems from cancer as...
7.
Penisson S, Lambert A, Tomasetti C
Nat Commun
. 2022 Nov;
13(1):7224.
PMID: 36433937
Recent evidence arising from DNA sequencing of healthy human tissues has clearly indicated that our organs accumulate a relevant number of somatic mutations due to normal endogenous mutational processes, in...
8.
Tie J, Cohen J, Lahouel K, Lo S, Wang Y, Kosmider S, et al.
N Engl J Med
. 2022 Jun;
386(24):2261-2272.
PMID: 35657320
Background: The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas...
9.
Lipscomb J, Horton S, Kuo A, Tomasetti C
Cancer
. 2022 Feb;
128 Suppl 4:892-908.
PMID: 35133662
Emerging data provide initial support for the concept that a single, minimally invasive liquid biopsy test, performed in conjunction with confirmatory radiologic or other diagnostic testing, when indicated, could be...
10.
Akshintala V, Sperna Weiland C, Bhullar F, Kamal A, Kanthasamy K, Kuo A, et al.
Lancet Gastroenterol Hepatol
. 2021 Jul;
6(9):733-742.
PMID: 34214449
Background: Non-steroidal anti-inflammatory drugs (NSAIDs), intravenous fluid, pancreatic stents, or combinations of these have been evaluated in randomised controlled trials (RCTs) for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis,...