Craig A McElroy
Overview
Explore the profile of Craig A McElroy including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
436
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0
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Recent Articles
1.
Miller K, He Y, Allen S, McElroy C, Callam C, Hadad C
Chem Res Toxicol
. 2025 Mar;
PMID: 40043018
Organophosphorus (OP) compounds pose a serious risk to human health by covalently modifying acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Currently approved oxime therapeutics can reactivate OP-inhibited AChE and BChE, despite significant...
2.
McElroy C, Ihms E, Yadav D, Holmquist M, Wadhwa V, Wysocki V, et al.
J Struct Biol X
. 2024 Jul;
10:100103.
PMID: 39035014
Cellular production of tryptophan is metabolically expensive and tightly regulated. The small zinc binding Anti-TRAP protein (AT), which is the product of the gene, is upregulated in response to accumulating...
3.
Lovins A, Miller K, Buck A, Ensey D, Homoelle R, Murtha M, et al.
ACS Chem Neurosci
. 2024 Apr;
15(9):1813-1827.
PMID: 38621296
Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a serious health risk to humans. While many therapeutics have been tested for treatment after OP exposure, there is still a need...
4.
Clay W, Buck A, He Y, Hernandez Sanchez D, Ward N, Lear J, et al.
Chem Res Toxicol
. 2024 Apr;
37(4):643-657.
PMID: 38556765
Organophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE), creating a cholinergic crisis in which death can occur. The phosphylated serine residue spontaneously dealkylates to the OP-aged form, which current therapeutics cannot...
5.
Vignaux P, Shriwas P, Revnew A, Agarwal G, Lane T, McElroy C, et al.
Chem Res Toxicol
. 2023 Aug;
36(9):1451-1455.
PMID: 37650603
CYP2C19 is an important enzyme for organophosphate pesticide (OPP) metabolism. Because the OPPs can be both substrates and inhibitors of CYP2C19, we screened 45 OPPs for their ability to inhibit...
6.
Gutti G, He Y, Coldren W, Lalisse R, Border S, Hadad C, et al.
J Biomol Struct Dyn
. 2023 Apr;
42(4):1733-1750.
PMID: 37114441
COVID-19, the disease responsible for the recent pandemic, is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main protease (Mpro) of SARS-CoV-2 is an essential proteolytic...
7.
Agarwal G, Tichenor H, Roo S, Lane T, Ekins S, McElroy C
Metabolites
. 2023 Apr;
13(4).
PMID: 37110155
Our current understanding of organophosphorus agent (pesticides and chemical warfare nerve agents) metabolism in humans is limited to the general transformation by cytochrome P450 enzymes and, to some extent, by...
8.
Buga A, Kackley M, Crabtree C, Bedell T, Robinson B, Stoner J, et al.
Clin Nutr ESPEN
. 2023 Mar;
54:277-287.
PMID: 36963874
Background: Single doses of exogenous ketone salts (KS) transiently increase circulating beta-hydroxybutyrate (BHB) (∼1 mM; 1-2 h) regardless of starting levels of ketosis; however, no studies have explored how sustained...
9.
Iqbal K, Khalid S, McElroy C, Adnan M, Khan G, Junaid Dar M
Nanomedicine (Lond)
. 2022 Oct;
17(20):1429-1447.
PMID: 36301316
To develop and evaluate detergent-free, triple-drug-loaded, hyaluronate-coated elastic nanovesicles (H-ENVs) for the topical treatment of cutaneous leishmaniasis. H-ENVs were developed and evaluated for vesicle size, entrapment efficiency, skin permeation and...
10.
Kackley M, Buga A, Crabtree C, Sapper T, McElroy C, Focht B, et al.
Brain Sci
. 2022 Sep;
12(9).
PMID: 36138878
Brain-Derived Neurotropic Factor (BDNF) expression is decreased in conditions associated with cognitive decline as well as metabolic diseases. One potential strategy to improve metabolic health and elevate BDNF is by...