Constantine A Simintiras
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Explore the profile of Constantine A Simintiras including associated specialties, affiliations and a list of published articles.
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22
Citations
204
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Recent Articles
1.
Sun F, Ali N, Londono-Vasquez D, Simintiras C, Qiao H, Ortega M, et al.
Nat Commun
. 2024 Nov;
15(1):9463.
PMID: 39487138
Unlike mild DNA damage exposure, DNA damage repair (DDR) is reported to be ineffective in full-grown mammalian oocytes exposed to moderate or severe DNA damage. The underlying mechanisms of this...
2.
Liu Q, Li C, Li Y, Wang L, Zhang X, Deng B, et al.
STAR Protoc
. 2023 Nov;
4(4):102703.
PMID: 37948186
Here, we present a protocol to isolate progenitor cells from mouse epididymal visceral adipose tissue and construct bulk RNA and assay for transposase-accessible chromatin with sequencing (ATAC-seq) libraries. We describe...
3.
Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, et al.
Cell Rep
. 2023 Mar;
42(3):112166.
PMID: 36857185
Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral...
4.
Alrabiah N, Simintiras C, Evans A, Lonergan P, Fair T
Reprod Fertil
. 2022 Dec;
PMID: 36547396
Follicular fluid (FF), a product of vascular transudate and granulosa and thecal cell secretions, is the milieu that has evolved to support oocyte growth and maturation which plays a central...
5.
Fernandez-Fuertes B, Rodriguez-Alonso B, Sanchez J, Simintiras C, Lonergan P, Rizos D
Anim Reprod
. 2022 Oct;
15(Suppl 1):751-764.
PMID: 36249838
The oviduct is a tubular organ comprising three distinct anatomical regions (the infundibulum, the ampulla and the isthmus) connecting the ovary and the uterus. Oviductal function is regulated by ovarian...
6.
Geisert R, Johns D, Pfeiffer C, Sullivan R, Lucas C, Simintiras C, et al.
Mol Reprod Dev
. 2022 Jun;
90(7):459-468.
PMID: 35736243
CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection...
7.
Simintiras C, Drum J, Liu H, Ortega M, Spencer T
Commun Biol
. 2022 Mar;
5(1):191.
PMID: 35233029
Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by endometrial...
8.
Simintiras C, Dhakal P, Ranjit C, Fitzgerald H, Balboula A, Spencer T
Proc Natl Acad Sci U S A
. 2021 Apr;
118(15).
PMID: 33876774
Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes to offspring susceptibility to chronic adult-onset disorders. However, our understanding of the biochemical composition and mechanisms underpinning...
9.
Simintiras C, Sanchez J, McDonald M, OCallaghan E, Aburima A, Lonergan P
Biol Reprod
. 2021 Feb;
104(5):1022-1033.
PMID: 33590828
Reproductive efficiency in livestock is a major driver of sustainable food production. The poorly understood process of ruminant conceptus elongation (a) prerequisites maternal pregnancy recognition, (b) is essential to successful...
10.
Sanchez J, Simintiras C, Lonergan P
Anim Reprod
. 2020 May;
16(3):376-385.
PMID: 32435281
Establishment of pregnancy in mammals requires reciprocal molecular communication between the conceptus and endometrium that modifies the endometrial transcriptome and uterine luminal milieu to support pregnancy. Due to the small...