Thomas E Spencer
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Explore the profile of Thomas E Spencer including associated specialties, affiliations and a list of published articles.
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253
Citations
7683
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Recent Articles
1.
Rahman M, Kim T, Barrier B, Spencer T, Kelleher A, Jeong J
FASEB J
. 2025 Mar;
39(5):e70436.
PMID: 40022603
Endometriosis, characterized by the growth of uterine-like tissue outside the uterus, causes chronic pain and infertility. Current diagnostic and therapeutic strategies have notable limitations, including delayed diagnosis and adverse effects....
2.
Davenport K, Lowke M, Ortega M, Kelleher A, Warren W, Spencer T
Biol Reprod
. 2025 Feb;
PMID: 39987557
A central determinant of successful reproduction is pregnancy establishment and maintenance that relies on proper development of the conceptus (embryo/fetus and associated extraembryonic membranes including the placenta). Pregnancy loss in...
3.
Kiser J, Seabury C, Neupane M, Moraes J, Herrick A, Dalton J, et al.
BMC Genomics
. 2025 Feb;
26(1):174.
PMID: 39984840
Background: The financial strain fertility issues cause the dairy cattle industry is substantial, with over $7 billion in lost revenue accrued annually due to a relatively low cow conception rate...
4.
Rizo J, Ahmad V, Pru J, Winuthayanon S, Challa S, Kim T, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2422694122.
PMID: 39883834
Understanding how epithelial cells in the female reproductive tract (FRT) differentiate is crucial for reproductive health, yet the underlying mechanisms remain poorly defined. At birth, FRT epithelium is highly malleable,...
5.
Peterson K, Freeman T, Poudel S, Behura S, Kakhniashvili D, Johnson D, et al.
Biol Reprod
. 2025 Jan;
PMID: 39775669
The bovine conceptus elongates near Day 16 of development and releases interferon-tau (IFNT), disrupting the endometrial luteolytic mechanism to sustain luteal P4 and pregnancy. Conceptus factors other than IFNT modify...
6.
Biase F, Moorey S, Schnuelle J, Rodning S, Ortega M, Spencer T
J Anim Sci Biotechnol
. 2024 Sep;
15(1):130.
PMID: 39267128
Background: MicroRNAs (miRNAs) are presented in the uterine lumen of many mammals, and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast...
7.
Fallon L, Lockhart K, Spencer T, Ortega M
Reprod Fertil Dev
. 2024 Sep;
36.
PMID: 39265060
Context Sires differ in their ability to produce viable blastocysts, yet our understanding of the cellular mechanisms regulated by the sire during early embryo development is limited. Aims The first...
8.
Silva J, Caldeira M, Moraes J, Sellmer Ramos I, Gull T, Ericsson A, et al.
Biol Reprod
. 2024 May;
111(2):332-350.
PMID: 38704744
Cows with metritis (uterine disease) during the first 1 to 2 weeks postpartum have lower pregnancy rates when inseminated later postpartum (typically >10 weeks). We hypothesized that metritis and the...
9.
Rizo J, Spencer T, Kelleher A
STAR Protoc
. 2024 Feb;
5(1):102894.
PMID: 38363685
Postnatal development of the uterus involves the specification of undifferentiated epithelium into uterine-type epithelium. That specification is regulated by stromal-epithelial interactions as well as intrinsic cell-specific transcription factors and gene...
10.
Sanchez J, Rabaglino M, Bages-Arnal S, McDonald M, Behura S, Spencer T, et al.
Theriogenology
. 2024 Jan;
218:26-34.
PMID: 38295677
In cattle, mating to intact, but not vasectomised, bulls has been shown to modify the endometrial transcriptome, suggesting an important role of sperm in the modulation of the uterine environment...