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Connor A West

Explore the profile of Connor A West including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 184
Followers 0
Related Specialties
Biochemistry
Molecular Biology
General Medicine
Top 10 Co-Authors
Anand S Mehta
Richard R Drake
Peggi M Angel
Hongyan Liang
Brian B Haab
Xiaowei Lu
Mengjun Wang
Colin T McDowell
Harmin P Herrera
David N Lewin
Published In
J Proteome Res
Mol Cell Proteomics
Adv Exp Med Biol
Methods Mol Biol
Anal Chem
Affiliations
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Recent Articles
1.
An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry
Wallace E, West C, McDowell C, Lu X, Bruner E, Mehta A, et al.
Sci Rep . 2024 Jan; 14(1):489. PMID: 38177192
N-glycosylation is an abundant post-translational modification of most cell-surface proteins. N-glycans play a crucial role in cellular functions like protein folding, protein localization, cell-cell signaling, and immune detection. As different...
2.
Optimization of Multiple Glycosidase and Chemical Stabilization Strategies for N-Glycan Isomer Detection by Mass Spectrometry Imaging in Formalin-Fixed, Paraffin-Embedded Tissues
West C, Lu X, Grimsley G, Norris-Caneda K, Mehta A, Angel P, et al.
Methods Mol Biol . 2021 Apr; 2271:303-316. PMID: 33908016
The analysis of N-glycan distributions in formalin-fixed, paraffin-embedded (FFPE) tissues by matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is an effective approach for characterization of many disease states. As...
3.
Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen-Defined Pancreatic Cancer Tissues
McDowell C, Klamer Z, Hall J, West C, Wisniewski L, Powers T, et al.
Mol Cell Proteomics . 2021 Feb; 20:100012. PMID: 33581409
The early detection of pancreatic ductal adenocarcinoma (PDAC) is a complex clinical obstacle yet is key to improving the overall likelihood of patient survival. Current and prospective carbohydrate biomarkers carbohydrate...
4.
New Enzymatic Approach to Distinguish Fucosylation Isomers of N-Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry
West C, Liang H, Drake R, Mehta A
J Proteome Res . 2020 May; 19(8):2989-2996. PMID: 32441096
Specific alterations in N-linked glycans, such as core fucosylation, are associated with many cancers and other disease states. Because of the many possible anomeric linkages associated with fucosylated -glycans, determination...
5.
A Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging
Black A, Liang H, West C, Wang M, Herrera H, Haab B, et al.
Anal Chem . 2019 Jun; 91(13):8429-8435. PMID: 31177770
A new platform for N-glycoprotein analysis from serum that combines matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) workflows with antibody slide arrays is described. Antibody panel based (APB) N-glycan...
6.
MALDI Mass Spectrometry Imaging of N-Linked Glycans in Tissues
Drake R, West C, Mehta A, Angel P
Adv Exp Med Biol . 2018 Nov; 1104:59-76. PMID: 30484244
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been used for two decades to profile the glycan constituents of biological samples. An adaptation of the method to tissues,...
7.
N-Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging
West C, Wang M, Herrera H, Liang H, Black A, Angel P, et al.
J Proteome Res . 2018 Aug; 17(10):3454-3462. PMID: 30110170
Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and accounts for more than 700,000 deaths annually. Changes in serum glycosylation have long been associated with...