Connie B Nichols
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Explore the profile of Connie B Nichols including associated specialties, affiliations and a list of published articles.
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37
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1183
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Recent Articles
1.
du Plooy L, Telzrow C, Nichols C, Probst C, Castro-Lopez N, Wormley Jr F, et al.
mBio
. 2024 Sep;
15(10):e0098124.
PMID: 39235249
Importance: Microbial proteins involved in human infectious diseases often need to be modified by specific chemical additions to be fully functional. Here, we explore the role of a particular protein...
2.
OMeara M, Rapala J, Nichols C, Alexandre A, Billmyre R, Steenwyk J, et al.
PLoS Genet
. 2024 Feb;
20(2):e1011158.
PMID: 38359090
Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation,...
3.
OMeara M, Rapala J, Nichols C, Alexandre C, Billmyre R, Steenwyk J, et al.
bioRxiv
. 2023 Aug;
PMID: 37645941
Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation,...
4.
Probst C, Hallas-Moller M, Ipsen J, Brooks J, Andersen K, Haon M, et al.
PLoS Pathog
. 2023 Apr;
19(4):e1010946.
PMID: 37099613
Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division. These morphological changes require reorganization of the cell wall, a structural feature external to...
5.
Thak E, Son Y, Lee D, Kim H, Kim J, Lee S, et al.
mBio
. 2022 Nov;
13(6):e0211222.
PMID: 36409123
The human-pathogenic yeast Cryptococcus neoformans assembles two types of -linked glycans on its proteins. In this study, we identified and functionally characterized the C. neoformans gene, encoding an α1,3-mannosyltransferase responsible...
6.
Wang Y, Xu F, Nichols C, Shi Y, Hellinga H, Alspaugh J, et al.
J Med Chem
. 2022 Oct;
65(20):13753-13770.
PMID: 36218371
Infections by fungal pathogens are difficult to treat due to a paucity of antifungals and emerging resistances. Next-generation antifungals therefore are needed urgently. We have developed compounds that prevent farnesylation...
7.
Perlatti B, Lan N, Xiang M, Earp C, Spraker J, Harvey C, et al.
J Ind Microbiol Biotechnol
. 2021 Feb;
48(9-10).
PMID: 33640980
Cryptococcus neoformans is a serious human pathogen with limited options for treatment. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition and...
8.
Nichols C
Curr Protoc
. 2021 Jan;
1(1):e27.
PMID: 33484487
Cryptococcus neoformans is an opportunistic fungal pathogen primarily targeting immunosuppressed populations in both resource-rich and resource-limited nations. Successful treatment is limited to a few antifungals that have become compromised by...
9.
Perlatti B, Nichols C, Alspaugh J, Gloer J, Bills G
Biomolecules
. 2020 Sep;
10(10).
PMID: 32993102
is a mycoparasitic fungus that can be found parasitizing wood-decay basidiomycetes in the southern USA. Organic solvent extracts of fermented strains of exhibited potent antimicrobial activity, including potent growth inhibition...
10.
Perlatti B, Harris G, Nichols C, Ekanayake D, Alspaugh J, Gloer J, et al.
J Nat Prod
. 2020 Sep;
83(9):2718-2726.
PMID: 32881504
Campafungin A is a polyketide that was recognized in the fitness test due to its antiproliferative and antihyphal activity. Its mode of action was hypothesized to involve inhibition of a...