Bruno Perlatti
Overview
Explore the profile of Bruno Perlatti including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
78
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Recent Articles
1.
Johnson C, Johnson C, Nuniz L, Perlatti B, Bills G, Tang Y
Chembiochem
. 2025 Feb;
:e202500003.
PMID: 40020202
We uncovered the biosynthetic pathway of the C-glycosylated depside arenicolin B from Phialomyces arenicola through genome mining, heterologous reconstitution and biochemical characterization. The biosynthetic gene cluster (BGC) of arenicolin B...
2.
Dunbar K, Perlatti B, Liu N, Cornelius A, Mummau D, Chiang Y, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2310522120.
PMID: 37983497
With the significant increase in the availability of microbial genome sequences in recent years, resistance gene-guided genome mining has emerged as a powerful approach for identifying natural products with specific...
3.
Zhang Y, Go E, Perlatti B, Wu L, Bills G, Ohashi M, et al.
J Am Chem Soc
. 2023 Mar;
145(12):6643-6647.
PMID: 36920241
The complete biosynthetic pathways of the potent antifungals AS2077715 () and funiculosin () are reconstituted and characterized. A five-enzyme cascade, including a multifunctional flavin-dependent monooxygenease and a repurposed methyltransferase, is...
4.
Yee D, Niwa K, Perlatti B, Chen M, Li Y, Tang Y
Nat Chem Biol
. 2023 Jan;
19(5):633-640.
PMID: 36702957
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to discovery of the so-called unknown (biosynthetic route)-unknown (molecular structure) natural products. Here we focused on a conserved...
5.
Boica Junior A, Costa E, de Souza B, Forim M, Perlatti B, da Cruz M
Bull Entomol Res
. 2022 May;
112(6):818-826.
PMID: 35509257
is an important pest of several crops in South America, including soybeans. Adults cause severe defoliation in soybean plants, and damage is significant when cotyledons are attacked. This study evaluated...
6.
Gorup L, Perlatti B, Kuznetsov A, Nascente P, Wendler E, Dos Santos A, et al.
RSC Adv
. 2022 May;
10(11):6259-6270.
PMID: 35495990
Metals capped with organochalcogenides have attracted considerable interest due to their practical applications, which include catalysis, sensing, and biosensing, due to their optical, magnetic, electrochemical, adhesive, lubrication, and antibacterial properties....
7.
Ardila J, Roberto de Alvarenga Junior B, Durango L, Soares F, Perlatti B, Cardoso J, et al.
Eur J Pharm Sci
. 2021 Jul;
165:105939.
PMID: 34284097
Forced degradation tests are studies used to assess the stability of active pharmaceutical ingredients (APIs) and their formulations. These tests are performed submitting the API under extreme conditions in order...
8.
Ekanayake D, Perlatti B, Swenson D, Poldmaa K, Bills G, Gloer J
J Nat Prod
. 2021 Jun;
84(7):2028-2034.
PMID: 34191504
The genus comprises fungi that colonize basidiomata of wood-inhabiting fungi, including important forest pathogens. Studies of fermentation cultures of an isolate (TFC201724) collected on the foothills of Himalayas, and closely...
9.
Liu N, Abramyan E, Cheng W, Perlatti B, Harvey C, Bills G, et al.
J Am Chem Soc
. 2021 Apr;
143(16):6043-6047.
PMID: 33857369
Lanosterol 14α-demethylase (CYP51) is an important target in the development of antifungal drugs. The fungal-derived restricticin and related molecules are the only examples of natural products that inhibit CYP51. Here,...
10.
Perlatti B, Lan N, Xiang M, Earp C, Spraker J, Harvey C, et al.
J Ind Microbiol Biotechnol
. 2021 Feb;
48(9-10).
PMID: 33640980
Cryptococcus neoformans is a serious human pathogen with limited options for treatment. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition and...