Colin Y C Lee
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Explore the profile of Colin Y C Lee including associated specialties, affiliations and a list of published articles.
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13
Citations
132
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Recent Articles
1.
Coates M, Richoz N, Tuong Z, Bowyer G, Lee C, Ferdinand J, et al.
Nat Immunol
. 2025 Jan;
26(2):215-229.
PMID: 39890933
Adaptive immunity is generated in lymphoid organs, but how these structures defend themselves during infection in humans is unknown. The nasal epithelium is a major site of viral entry, with...
2.
Hasegawa T, Lee C, Hotchen A, Fleming A, Singh R, Suzuki K, et al.
Nat Immunol
. 2024 Nov;
25(12):2270-2283.
PMID: 39587345
A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes (ICs). How such stimuli access joints...
3.
Lee C, McCaffrey J, McGovern D, Clatworthy M
J Allergy Clin Immunol
. 2024 Nov;
155(3):663-677.
PMID: 39522655
Immune responses require complex, spatially coordinated interactions between immune cells and their tissue environment. For decades, we have imaged tissue sections to visualize a limited number of immune-related macromolecules in...
4.
Bahadori K, Lee C, Ferdinand J, Cabantous M, Butler A, Rouhani F, et al.
Transplantation
. 2024 Oct;
109(2):332-345.
PMID: 39350310
Background: Ex situ normothermic perfusion (ESNP) is a method to evaluate and potentially recondition organs before transplantation. However, increased expression of inflammatory molecules, including by tissue-resident immune cells, may occur...
5.
Stewart A, Loudon K, Routledge M, Lee C, Trotter P, Richoz N, et al.
Sci Transl Med
. 2024 Sep;
16(766):eadh5090.
PMID: 39321268
Lower urinary tract infection (UTI) is common but only rarely complicated by pyelonephritis. However, the mechanisms preventing extension to the kidney are unclear. Here, we identified neutrophil extracellular traps (NETs)...
6.
Fitzpatrick Z, Ghabdan Zanluqui N, Rosenblum J, Tuong Z, Lee C, Chandrashekhar V, et al.
Nature
. 2024 Mar;
628(8008):612-619.
PMID: 38509366
There is increasing interest in how immune cells in the meninges-the membranes that surround the brain and spinal cord-contribute to homeostasis and disease in the central nervous system. The outer...
7.
Lee C, Kennedy B, Richoz N, Dean I, Tuong Z, Gaspal F, et al.
Nat Commun
. 2024 Jan;
15(1):682.
PMID: 38267413
Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule...
8.
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Dean I, Lee C, Tuong Z, Li Z, Tibbitt C, Willis C, et al.
Nat Commun
. 2024 Jan;
15(1):683.
PMID: 38267402
Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mechanistic underpinning...
9.
Atallah E, Welsh S, OCarrigan B, Oshaughnessy A, Dolapo I, Kerr A, et al.
JHEP Rep
. 2023 Sep;
5(10):100851.
PMID: 37727807
Background & Aims: Checkpoint inhibitors (CPI) account for increasing numbers of drug-induced liver injury (DILI) cases. We aimed to determine the incidence rate and risk factors associated with checkpoint inhibitor-induced...
10.
Ferreira I, Lee C, Foster W, Abdullahi A, Dratva L, Tuong Z, et al.
Cell Rep
. 2023 Aug;
42(8):112991.
PMID: 37590132
Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here,...