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Colin L Weeks

Explore the profile of Colin L Weeks including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 197
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Recent Articles
1.
Petersen T, Balakrishnan G, Weeks C
Dalton Trans . 2015 Jun; 44(28):12824-31. PMID: 26100962
Determining the mechanism of metal-organic framework (MOF) crystal growth is important for the development of more efficient and reliable synthetic methods. Resonance Raman spectroscopy has been used for the first...
2.
Weeks C, Polishchuk A, Getahun Z, DeGrado W, Spiro T
J Raman Spectrosc . 2011 Sep; 39(11):1606-1613. PMID: 20648227
The incorporation of unnatural amino acids into proteins that act as spectroscopic probes can be used to study protein structure and function. One such probe is 4-cyanophenylalanine (PheCN), the nitrile...
3.
Kabil O, Weeks C, Carballal S, Gherasim C, Alvarez B, Spiro T, et al.
Biochemistry . 2011 Aug; 50(39):8261-3. PMID: 21875066
Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S. The presence of a heme cofactor in...
4.
Weeks C, Singh S, Madzelan P, Banerjee R, Spiro T
J Am Chem Soc . 2009 Sep; 131(35):12809-16. PMID: 19722721
Cystathionine beta-synthase (CBS) plays a central role in homocysteine metabolism, and malfunction of the enzyme leads to homocystinuria, a devastating metabolic disease. CBS contains a pyridoxal 5'-phosphate (PLP) cofactor which...
5.
Singh S, Madzelan P, Stasser J, Weeks C, Becker D, Spiro T, et al.
J Inorg Biochem . 2009 Feb; 103(5):689-97. PMID: 19232736
In humans, cystathionine beta-synthase (CBS) is a hemeprotein, which catalyzes a pyridoxal phosphate (PLP)-dependent condensation reaction. Changes in the heme environment are communicated to the active site, which is approximately...
6.
Balakrishnan G, Weeks C, Ibrahim M, Soldatova A, Spiro T
Curr Opin Struct Biol . 2008 Jul; 18(5):623-9. PMID: 18606227
Raman spectroscopy can provide unique information on the evolution of structure in proteins over a wide range of time scales; the picosecond to millisecond range can be accessed with pump-probe...
7.
Weeks C, Anbar A, Wasylenki L, Spiro T
J Phys Chem A . 2007 Aug; 111(49):12434-8. PMID: 17715906
Analytical studies have found an enrichment of the lighter Mo isotopes in oxic marine sediments compared to seawater, with isotope fractionation factors of -1.7 to -2.0 per thousand for Delta97/95Mosediment-seawater....
8.
Puranik M, Weeks C, Lahaye D, Kabil O, Taoka S, Nielsen S, et al.
J Biol Chem . 2006 Mar; 281(19):13433-13438. PMID: 16505479
Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction. It also contains a heme cofactor to which carbon monoxide (CO) or nitric oxide can...
9.
Chapman K, Southon P, Weeks C, Kepert C
Chem Commun (Camb) . 2005 Jun; (26):3322-4. PMID: 15983661
The family of dehydrated nanoporous Prussian Blue analogues, M(II)3[Co(III)(CN)6]2 (M(II) = Mn, Fe, Co, Ni, Cu, Zn, Cd), which contain coordinatively unsaturated divalent metal cations, undergoes reversible sorption of hydrogen...
10.
Weeks C, Levina A, Dillon C, Turner P, Fenton R, Lay P
Inorg Chem . 2004 Nov; 43(24):7844-56. PMID: 15554650
The first structurally characterized Cr(V) dioxo complex, cis-[CrV(O)2(phen)2](BF4) (2, phen=1,10-phenanthroline) has been synthesized by the oxidation of a related Cr(III) complex, cis-[Cr(III)(phen)2(OH2)2](NO3)3.2.5H2O (1, characterized by X-ray crystallography), with NaOCl in...