Colin D McCaig
Overview
Explore the profile of Colin D McCaig including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
2541
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Recent Articles
1.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():521-529.
PMID: 39838023
Since the first Chapter dealt with the well-known charge-charge interactions familiar to biologists, this concluding Chapter introduces some key electrical forces, probably much less familiar, perhaps even unknown. LLPS (liquid...
2.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():453-520.
PMID: 39838022
This penultimate chapter is based on a single paper published in Nature in 2022. I have used it specifically as an exemplar, in this case to show that memory improvement...
3.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():419-452.
PMID: 39838021
ATP synthase is a rotary motor enzyme that drives the formation of ATP from ADP and P and uses multiple electrical forces to do this. This chapter outlines the exquisite...
4.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():411-417.
PMID: 39838020
Packaging of DNA into viruses in some cases involves remarkably sophisticated electrical control mechanisms. One example is how the T4 bacteriophage uses an electrostatically driven motor to pump DNA into...
5.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():361-410.
PMID: 39838019
One of the most important and challenging biological events of recent times has been the pandemic caused by SARS-CoV-2. Since the underpinning argument behind this book is the ubiquity of...
6.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():339-359.
PMID: 39838018
Pre- and post-synaptic events are regulated by liquid-liquid phase separation and this phenomenon requires multiple electrical forces. Both axonal transport and the organization of postsynaptic excitatory and inhibitory receptors are...
7.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():273-338.
PMID: 39838017
Several neurological diseases arise from abnormal protein aggregation within neurones and this is closely regulated by phase separation. One such is motor neurone disease and aberrant aggregation of superoxide dismutase....
8.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():251-272.
PMID: 39838016
Multiple epigenetic modulations occur to chromatin rather than to DNA itself and these influence gene expression or gene silencing profoundly. Both the creation of these post-translational modifications and the mechanisms...
9.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():239-250.
PMID: 39838015
It is now well-recognized that biological catalysis depends crucially on spatially regulated electrical forces for optimal efficiency. Several examples of the mechanisms underpinning this will be covered, as will the...
10.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():195-237.
PMID: 39838014
Ribosomes use multiple electrical forces to regulate new protein construction, to ensure efficient protein cotranslation, chaperoning, and folding. When these electrical regulatory forces are disrupted as in point charge mutations,...