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Electric Forces and ATP Synthesis

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Date 2025 Jan 21
PMID 39838021
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Abstract

ATP synthase is a rotary motor enzyme that drives the formation of ATP from ADP and P and uses multiple electrical forces to do this. This chapter outlines the exquisite use of these electrical forces to generate the high energy phosphates on which all our lives depend. Vacuolar ATPases and the ADP/ATP carrier also are explored.

References
1.
Ahmad Z, Okafor F, Laughlin T . Role of Charged Residues in the Catalytic Sites of Escherichia coli ATP Synthase. J Amino Acids. 2012; 2011:785741. PMC: 3268026. DOI: 10.4061/2011/785741. View

2.
Almendro-Vedia V, Natale P, Valdivieso Gonzalez D, Lillo M, Aragones J, Lopez-Montero I . How rotating ATP synthases can modulate membrane structure. Arch Biochem Biophys. 2021; 708:108939. DOI: 10.1016/j.abb.2021.108939. View

3.
Badocha M, Wieczor M, Marciniak A, Kleist C, Grubmuller H, Czub J . Molecular mechanism and energetics of coupling between substrate binding and product release in the F-ATPase catalytic cycle. Proc Natl Acad Sci U S A. 2023; 120(8):e2215650120. PMC: 9974484. DOI: 10.1073/pnas.2215650120. View

4.
Bornhovd C, Vogel F, Neupert W, Reichert A . Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes. J Biol Chem. 2006; 281(20):13990-8. DOI: 10.1074/jbc.M512334200. View

5.
BOYER P . The ATP synthase--a splendid molecular machine. Annu Rev Biochem. 1997; 66:717-49. DOI: 10.1146/annurev.biochem.66.1.717. View