Colin D McCaig
Overview
Explore the profile of Colin D McCaig including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
2541
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Recent Articles
11.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():147-193.
PMID: 39838013
Nucleic acids are highly charged, and electrical forces are involved heavily in how our DNA is compacted and packaged into such a small space, how chromosomes are formed, and how...
12.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():115-145.
PMID: 39838012
Rapid tissue repair is also needed in the event of damage to blood vessels. Most of the essential steps that prevent us from bleeding to death involve the functions of...
13.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():103-113.
PMID: 39838011
Damage to the cell membrane can be life threatening for single-celled organisms. Several mechanisms of single-cell wound healing occur and aspects of these are regulated by electrical forces.
14.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():89-101.
PMID: 39838010
Cell membranes contain multiple charged lipids that bind proteins dynamically and their spatial organization on the inner/outer membrane leaflet, or in spatially localized areas has considerable biological importance. Myristoylated alanine-rich...
15.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():61-87.
PMID: 39838009
Epithelial tissues and the basement membranes they sit on did not appear for billions of years. Their appearance was delayed most likely by a lack of oxygen, which is required...
16.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():53-60.
PMID: 39838008
Epithelial sheets evolved the capacity to fold and reform to create a lumen and therefore new environments. For humans, forming a lumen during gastrulation has been viewed as perhaps the...
17.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():47-52.
PMID: 39838007
Once multicellularity was thriving, a key development involved the emergence of epithelial layers that separated "inside" from "outside". Most epithelia then generate their own transepithelial electrical signals. So electrical forces...
18.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187:39-46.
PMID: 39838006
Multiple single-celled life forms existed for millennia before some individual cells found ways of gathering together to form multicellular organisms. Several of the key elements that drove this step-change in...
19.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():29-38.
PMID: 39838005
Electrical forces are widespread in single-celled organisms and underpin sophisticated communication systems. Bacterial biofilm colonies, for example, attract new members electrically. Bacteria also join together end to end and engage...
20.
McCaig C
Rev Physiol Biochem Pharmacol
. 2025 Jan;
187():19-28.
PMID: 39838004
How did life come into existence? How was the first membrane formed on Earth? And where? What were the conditions that promoted membrane creation and how were electrical forces essential...